文章：

脂肪酸β-氧化通过miRNA-328-3p-CPT1A途径促进乳腺癌的发生和转移

Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway 

原文发布日期：2021-05-27 

英文摘要：

MicroRNAs (miRNA) have been shown to be associated with tumor diagnosis, prognosis, and therapeutic response. MiR-328-3p plays a significant role in breast cancer growth; however, its actual function and how it modulates specific biological functions is poorly understood. Here, miR-328-3p was significantly downregulated in breast cancer, especially in patients with metastasis. Mitochondrial carnitine palmitoyl transferase 1a (CPT1A) is a downstream target gene in the miR-328-3p-regulated pathway. Furthermore, the miR-328-3p/CPT1A/fatty acid β-oxidation/stemness axis was shown responsible for breast cancer metastasis. Collectively, this study revealed that miR-328-3p is a potential therapeutic target for the treatment of breast cancer patients with metastasis, and also a model for the miRNA-fatty acid β-oxidation-stemness axis, which may assist inunderstanding the cancer stem cell signaling functions of miRNA. 

摘要翻译： 

MicroRNAs（miRNA）已被证实与肿瘤诊断、预后及治疗反应密切相关。MiR-328-3p在乳腺癌生长中起重要作用，但其实际功能及调控特定生物学作用的具体机制尚不明确。本研究发现，miR-328-3p在乳腺癌中表达显著下调，尤其在发生转移的患者组织中。线粒体肉碱棕榈酰转移酶1a（CPT1A）是miR-328-3p调控通路的下游靶基因。进一步研究证实，miR-328-3p/CPT1A/脂肪酸β氧化/干性轴是驱动乳腺癌转移的关键机制。综上所述，本研究不仅揭示miR-328-3p可作为治疗转移性乳腺癌患者的潜在靶点，还构建了"miRNA-脂肪酸β氧化-干性"调控轴模型，为理解miRNA在癌症干细胞信号传导中的作用提供了新视角。

原文链接：

Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway