文章：

ESCRT-III介导的膜修复在细胞死亡和肿瘤抵抗中的作用

ESCRT-III-mediated membrane repair in cell death and tumor resistance 

原文发布日期：2020-07-15 

英文摘要：

The plasma membrane is made of glycerophospholipids that separate the inner and outer parts of the cell. Under physiological conditions, it acts as a barrier and gatekeeper to protect cells from the environment. In pathological situations, it undergoes structural and functional changes, resulting in cell damage. Indeed, plasma membrane damage caused by various stresses (e.g., hypoxia, nutritional deficiencies, ultraviolet radiation, and chemotherapeutic agents) is one of the hallmarks of cell death. Phosphatidylserine exposure and plasma membrane blebbing usually occurs in apoptotic cells, while necrotic cells lose the integrity of the plasma membrane and thereby release intracellular damage-associated molecular patterns. In contrast, the endosomal sorting complex required for transport-III (ESCRT-III), an evolutionarily conserved protein complex with membrane fission machinery, plays a key role in the repair of damaged plasma membranes in various types of regulated cell death, such as necroptosis, pyroptosis, and ferroptosis. These emerging findings indicate that ESCRT-III is a potential target to overcome drug resistance during tumor therapy. 

摘要翻译： 

细胞质膜由甘油磷脂构成，将细胞内外部分隔开。在生理条件下，它作为屏障和看门人保护细胞免受环境侵害；在病理情况下，则会发生结构和功能改变，导致细胞损伤。事实上，由缺氧、营养缺乏、紫外线辐射和化疗药物等多种应激源引起的质膜损伤，是细胞死亡的重要标志之一。凋亡细胞通常会出现磷脂酰丝氨酸外翻和质膜起泡现象，而坏死细胞则会丧失质膜完整性，从而释放细胞内的损伤相关分子模式。相比之下，运输所需内体分选复合物-III（ESCRT-III）——一种具有膜裂变机制的进化保守蛋白复合物，在坏死性凋亡、焦亡和铁死亡等多种调节性细胞死亡中，对受损质膜的修复起着关键作用。这些新发现表明，ESCRT-III有望成为肿瘤治疗中克服耐药性的潜在靶点。

原文链接：

ESCRT-III-mediated membrane repair in cell death and tumor resistance