文章：

环状RNA：癌变和非癌变皮肤病的表观遗传调控因子

Circular RNAs: epigenetic regulators in cancerous and noncancerous skin diseases

原文发布日期：2019-09-03 

英文摘要：

The most frequent kind of malignancy in the universe is skin cancer, which has been categorized into non-melanoma and melanoma skin cancer. There are no complete information of the skin carcinogenesis process. A variety of external and internal agents contribute to the non-melanoma and melanoma skin cancer pathogenesis. These factors are epigenetic changes, X-rays, genetic, arsenic compounds, UV rays, and additional chemical products. It was found that there could be a relationship between the appearing novel and more suitable therapies for participants in this class of diseases and detection of basic molecular paths. A covalently closed loop structure bond connecting the 5′ and 3′ ends characterizes a new group of extensively expressed endogenous regulatory RNAs, which are called circular RNAs (circRNAs). Mammals commonly express circRNAs. They are of high importance in tumorigenesis. Multiple lines evidence indicated that a variety of circular RNAs are associated with initiation and development of skin-related diseases such as skin cancers. Given that different circular RNAs (hsa_circ_0025039, hsa_circRNA006612, circRNA005537, and circANRIL) via targeting various cellular and molecular targets (e.g., CDK4, DAB2IP, ZEB1, miR-889, and let-7c-3p) exert their effects on skin cancers progression. Herein, for first time, we summarized different circular RNAs in skin cancers and noncancerous diseases. Moreover, we highlighted crosstalk between circular RNAs and ceRNAs in cancerous conditions. 

摘要翻译： 

皮肤癌是全球最为常见的恶性肿瘤，可分为非黑色素瘤性皮肤癌和黑色素瘤性皮肤癌两类。目前对皮肤癌发生过程的认知尚不完整。多种外源性及内源性因素共同参与非黑色素瘤与黑色素瘤性皮肤癌的发病机制，这些因素包括表观遗传学改变、X射线、遗传因素、砷化合物、紫外线以及其他化学物质。研究发现，针对此类疾病的新型高效疗法研发与基础分子通路的揭示可能存在关联。

环状RNA（circRNAs）是一类新型广泛表达的内源性调控RNA，其特征在于5'端与3'端通过共价键连接形成闭合环状结构。哺乳动物体内普遍表达环状RNA，这类分子在肿瘤发生过程中具有重要作用。多项证据表明多种环状RNA与皮肤相关疾病（包括皮肤癌）的起始和发展密切相关。特定环状RNA（如hsa_circ_0025039、hsa_circRNA006612、circRNA005537和circANRIL）通过靶向不同细胞及分子靶点（例如CDK4、DAB2IP、ZEB1、miR-889和let-7c-3p）对皮肤癌进展产生影响。本文首次系统综述了环状RNA在皮肤癌与非癌性皮肤疾病中的作用，并重点探讨了癌症状态下环状RNA与竞争性内源RNA（ceRNA）之间的交互调控机制。

原文链接：

Circular RNAs: epigenetic regulators in cancerous and noncancerous skin diseases