文章：

环状RNA在调控甲状腺癌特征中的新兴作用

Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer 

原文发布日期：2024-02-05 

英文摘要：

Thyroid cancer is a prevalent endocrine malignancy with increasing incidence in recent years. Although most thyroid cancers grow slowly, they can become refractory, leading to a high mortality rate once they exhibit recurrence, metastasis, resistance to radioiodine therapy, or a lack of differentiation. However, the mechanisms underlying these malignant characteristics remain unclear. Circular RNAs, a type of closed-loop non-coding RNAs, play multiple roles in cancer. Several studies have demonstrated that circular RNAs significantly influence the development of thyroid cancers. In this review, we summarize the circular RNAs identified in thyroid cancers over the past decade according to the hallmarks of cancer. We found that eight of the 14 hallmarks of thyroid cancers are regulated by circular RNAs, whereas the other six have not been reported to be correlated with circular RNAs. This review is expected to help us better understand the roles of circular RNAs in thyroid cancers and accelerate research on the mechanisms and cure strategies for thyroid cancers. 

摘要翻译： 

甲状腺癌是一种常见的内分泌恶性肿瘤，近年来发病率呈上升趋势。尽管大多数甲状腺癌生长缓慢，但可能发展为难治性肿瘤，一旦出现复发、转移、抵抗放射性碘治疗或去分化特征，死亡率会显著升高。然而，这些恶性特征的潜在机制尚不明确。环状RNA作为一种闭环非编码RNA，在癌症中发挥多重作用。多项研究表明环状RNA对甲状腺癌的发展具有重要影响。本文根据癌症特征标志，系统总结了过去十年中甲状腺癌领域发现的环状RNA。我们发现甲状腺癌的14个特征标志中有8个受到环状RNA的调控，而其余6个尚未见与环状RNA相关性的报道。本综述有助于更好地理解环状RNA在甲状腺癌中的作用，并推动甲状腺癌机制研究和治疗策略开发。

原文链接：

Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer