文章：

RNA修饰与长链非编码RNA相互作用在癌症中的新兴角色

Emerging role of RNA modification and long noncoding RNA interaction in cancer

原文发布日期：2024-02-14 

英文摘要：

RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression of cancer through multiple pathways. The function and expression of these epigenetic regulators have gradually become a hot topic in cancer research. Mutation and regulation of noncoding RNA, especially lncRNA, play a major role in cancer. Generally, lncRNAs exert tumor-suppressive or oncogenic functions and its dysregulation can promote tumor occurrence and metastasis. In this review, we summarize N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine modifications in lncRNAs. Furthermore, we discuss the relationship between epigenetic RNA modification and lncRNA interaction and cancer progression in various cancers. Therefore, this review gives a comprehensive understanding of the mechanisms by which RNA modification affects the progression of various cancers by regulating lncRNAs, which may shed new light on cancer research and provide new insights into cancer therapy. 

摘要翻译： 

RNA修饰，特别是N6-甲基腺苷、5-甲基胞嘧啶和N7-甲基鸟苷甲基化，通过多种途径参与癌症的发生与发展。这些表观遗传调控因子的功能与表达已逐渐成为癌症研究的热点。非编码RNA（尤其是长链非编码RNA）的突变与调控在癌症中起重要作用。通常lncRNA具有抑癌或致癌功能，其失调会促进肿瘤发生与转移。本文综述了lncRNA中N6-甲基腺苷、5-甲基胞嘧啶和N7-甲基鸟苷修饰的研究进展，并探讨了各类癌症中表观遗传RNA修饰与lncRNA相互作用及癌症进展的关联。本综述通过阐述RNA修饰通过调控lncRNAs影响多种癌症进展的机制，为癌症研究提供新思路，并为癌症治疗带来新见解。

原文链接：

Emerging role of RNA modification and long noncoding RNA interaction in cancer