文章目录

慢性肝病使肠道粪肠球菌定植促进肝癌的发生

原文发布日期：2021-09-27

英文摘要：

Gut dysbiosis is observed in chronic hepatobiliary diseases and is frequently associated with liver carcinogenesis; however, the extent and specific mechanisms triggered by alterations in the microbiota mediating tumorigenesis in these patients remain unclear. Here we show that Enterococcus faecalis is abundant in the microbiota of patients with hepatitis C virus-related chronic liver disease. Xenotransplantation of gut microbiota from these patients increased the number of spontaneous liver tumors in mice and enhanced susceptibility to liver carcinogens. Hepatic colonization by gelE-positive E. faecalis increased liver expression of proliferative genes in a TLR4–Myd88-dependent manner, leading to liver tumorigenesis. Moreover, decreased fecal deoxycholic acid levels were associated with colonization by E. faecalis. Overall, these data identify E. faecalis as a key promoter of liver carcinogenesis.

摘要翻译：

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文章：

慢性肝病使肠道粪肠球菌定植促进肝癌的发生

Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis

原文发布日期：2021-09-27

英文摘要：

Gut dysbiosis is observed in chronic hepatobiliary diseases and is frequently associated with liver carcinogenesis; however, the extent and specific mechanisms triggered by alterations in the microbiota mediating tumorigenesis in these patients remain unclear. Here we show that Enterococcus faecalis is abundant in the microbiota of patients with hepatitis C virus-related chronic liver disease. Xenotransplantation of gut microbiota from these patients increased the number of spontaneous liver tumors in mice and enhanced susceptibility to liver carcinogens. Hepatic colonization by gelE-positive E. faecalis increased liver expression of proliferative genes in a TLR4–Myd88-dependent manner, leading to liver tumorigenesis. Moreover, decreased fecal deoxycholic acid levels were associated with colonization by E. faecalis. Overall, these data identify E. faecalis as a key promoter of liver carcinogenesis.

摘要翻译：

肝胆疾病中的肠道微生态失调（Gut dysbiosis）在慢性肝胆疾病中被观察到，并经常与肝癌的发生有关；然而，在这些患者的肿瘤发生过程中，由于微生物群的改变引起的程度和具体机制尚不明确。我们发现，在患有与肝炎相关性状的慢性肝病的患者肠道微生态中，球虫科属（Enterococcus faecalis）菌群非常丰富。通过将来自这些患者的肠道微生态移植到小鼠体内，发现自发性肝脏肿瘤的数量增加了，并且增加了对肝癌原发的易感性。肝部被致敏的球虫E. faecalis positive gelE-阳性菌群（E. faecalis positive gelE）在肝脏中促进了增殖基因的表达，这种效应依赖于TLR4和Myd88信号通路。此外，粪内脱氧胆酸（FODAC）水平降低与致敏性有关。总体而言，这些数据表明了球虫科属菌群是肝癌发生的关键促进因子。