文章：

泛凋亡：连接细胞凋亡、焦亡与坏死性凋亡在癌症进展与治疗中的桥梁

PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment

原文发布日期：2024-03-29 

英文摘要：

This comprehensive review explores the intricate mechanisms of PANoptosis and its implications in cancer. PANoptosis, a convergence of apoptosis, pyroptosis, and necroptosis, plays a crucial role in cell death and immune response regulation. The study delves into the molecular pathways of each cell death mechanism and their crosstalk within PANoptosis, emphasizing the shared components like caspases and the PANoptosome complex. It highlights the significant role of PANoptosis in various cancers, including respiratory, digestive, genitourinary, gliomas, and breast cancers, showing its impact on tumorigenesis and patient survival rates. We further discuss the interwoven relationship between PANoptosis and the tumor microenvironment (TME), illustrating how PANoptosis influences immune cell behavior and tumor progression. It underscores the dynamic interplay between tumors and their microenvironments, focusing on the roles of different immune cells and their interactions with cancer cells. Moreover, the review presents new breakthroughs in cancer therapy, emphasizing the potential of targeting PANoptosis to enhance anti-tumor immunity. It outlines various strategies to manipulate PANoptosis pathways for therapeutic purposes, such as targeting key signaling molecules like caspases, NLRP3, RIPK1, and RIPK3. The potential of novel treatments like immunogenic PANoptosis-initiated therapies and nanoparticle-based strategies is also explored. 

摘要翻译： 

本综述深入探讨了PANoptosis（泛凋亡）的复杂机制及其在癌症中的重要意义。作为一种整合了细胞凋亡、焦亡和坏死性凋亡的协同细胞死亡形式，PANoptosis在细胞死亡和免疫应答调控中起着关键作用。研究详细阐述了各类细胞死亡方式的分子通路及其在PANoptosis中的交互作用，重点强调了半胱天冬酶（caspases）和PANoptosome复合体等共享组分。文章系统揭示了PANoptosis在呼吸系统、消化系统、泌尿生殖系统肿瘤以及胶质瘤、乳腺癌等多种癌症中的重要作用，展示了其对肿瘤发生和患者生存率的显著影响。我们进一步探讨了PANoptosis与肿瘤微环境（TME）的复杂关联，阐明其如何调控免疫细胞行为及肿瘤进展，着重分析了不同免疫细胞的功能及其与癌细胞的相互作用。此外，本综述介绍了癌症治疗领域的新突破，强调靶向PANoptosis在增强抗肿瘤免疫方面的潜力，概述了通过干预关键信号分子（如caspases、NLRP3、RIPK1和RIPK3）来调控PANoptosis通路的治疗策略，并探讨了免疫原性PANoptosis启动疗法和纳米颗粒技术等新型治疗方法的应用前景。

原文链接：

PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment