文章：

LIPG：炎症和癌症调节剂

LIPG: an inflammation and cancer modulator

原文发布日期：2020-06-23 

英文摘要：

Endothelial lipase (LIPG/EL) performs fundamental and vital roles in the human body, including cell composition, cytokine expression, and energy provision. Since LIPG predominantly functions as a phospholipase as well as presents low levels of triglyceride lipase activity, it plays an essential role in lipoprotein metabolism, and involves in the metabolic syndromes such as inflammatory response and atherosclerosis. Cytokines significantly affect LIPG expression in endothelial cells in many diseases. Recently, it is suggested that LIPG contributes to cancer initiation and progression, and LIPG attached increasing importance to its potential for future targeted therapy. 

摘要翻译：

内皮脂肪酶（LIPG/EL）在人体中发挥着基础而关键的作用，涉及细胞构成、细胞因子表达及能量供应等多个方面。由于LIPG主要发挥磷脂酶功能且仅呈现较低水平的甘油三酯脂肪酶活性，它在脂蛋白代谢中扮演重要角色，并参与炎症反应和动脉粥样硬化等代谢综合征过程。多种疾病中，细胞因子会显著影响内皮细胞的LIPG表达。近年研究表明，LIPG参与癌症的发生与发展进程，其作为潜在靶向治疗靶点的价值日益受到重视。

原文链接：

LIPG: an inflammation and cancer modulator