文章：

碱中毒：癌症治疗的新武器

Alkaliptosis: a new weapon for cancer therapy

原文发布日期：2019-08-30 

英文摘要：

Malignant tumors are one of the major causes of death worldwide, and the development of better treatments is urgently needed. There are many types of cancer treatment, such as surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapy, that might improve patient outcomes in a genotype- and stage-dependent manner. The main goal of cancer therapy is to inhibit biological capabilities of tumors and eventually eliminate the cancer cells. However, cancer cells are well known to escape apoptosis, a form of programmed cell death that was first described in studies of cell development and tissue remodelling. Increasing our understanding of cell death may result in new anticancer approaches that target types of nonapoptotic cell death, such as necroptosis, ferroptosis, autophagy-dependent cell death, and alkaliptosis. Notably, alkaliptosis, a pH-dependent form of regulated cell death, has been recently identified as a new strategy for cancer therapy across multiple tumor types, especially in pancreatic cancer. 

摘要翻译： 

恶性肿瘤是全球主要致死原因之一，亟需开发更有效的治疗方法。目前存在多种癌症治疗手段，如手术、化疗、放疗、免疫疗法及靶向治疗，这些疗法可根据基因分型和分期以改善患者预后。癌症治疗的核心目标是抑制肿瘤的生物学功能并最终清除癌细胞。然而，众所周知癌细胞能够逃逸细胞凋亡——这是一种最早在细胞发育和组织重塑研究中被描述的程序性细胞死亡方式。深化对细胞死亡机制的理解，可能催生靶向非凋亡性细胞死亡方式的新型抗癌策略，例如坏死性凋亡、铁死亡、自噬依赖性细胞死亡以及碱死亡。值得注意的是，碱死亡作为一种pH值依赖的调节性细胞死亡方式，近期已被证实可作为治疗多种肿瘤（尤其是胰腺癌）的新型策略。

原文链接：

Alkaliptosis: a new weapon for cancer therapy