文章：

血脑屏障的改变作为肺癌脑转移的始动因素：一个老故事的新视角

Blood-brain barrier alterations as an initiator of brain metastasis from lung cancer: a new take on an old story

原文发布日期：2025-06-02

英文摘要：

Lung cancer is the most common primary tumor associated with brain metastases. Currently, the molecular mechanisms underlying the pathogenesis of lung cancer brain metastasis (LCBM) have not been fully elucidated and effective therapeutic strategies for treating this disease are still lacking. The blood-brain barrier (BBB) is a selectively permeable membrane and is crucial in maintaining brain homeostasis. Increasing evidence from clinical and pre-clinical studies indicated that metastatic circulating tumor cells from lung cancer can affect the cellular biology of BBB components, and destruct its integrity as well as function to penetrate the BBB to clone in the brain parenchyma, therein producing malignant secondary tumors. Therefore, in this review, we aim to discuss about the involvement of BBB alterations during the initiation of LCBM and the cellular and molecular mechanisms underlying. A better understanding of these pathophysiological processes may help open avenues to develop new therapeutic strategies to prevent or treat this notorious disease.

摘要翻译：

肺癌是脑转移中最常见的原发性肿瘤。目前，肺癌脑转移（LCBM）的发病分子机制尚未完全阐明，且仍缺乏有效的治疗策略。血脑屏障（BBB）是一种选择性半透膜，对维持大脑稳态至关重要。越来越多的临床和临床前研究表明，肺癌循环肿瘤细胞可影响血脑屏障组成细胞的生物学特性，破坏其完整性和功能，从而穿透血脑屏障在脑实质中克隆形成恶性继发性肿瘤。因此，本综述旨在探讨血脑屏障在LCBM发生过程中的改变及其涉及的细胞与分子机制。深入理解这些病理生理过程或有助于开辟新途径，研发预防和治疗这一危重疾病的新策略。

原文链接：

Blood-brain barrier alterations as an initiator of brain metastasis from lung cancer: a new take on an old story