文章：

PROM1和PROM2表达差异调节癌症临床预后：一项多组学分析

PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis

原文发布日期：2019-06-05 

英文摘要：

Prominin 1 (PROM1) is considered a biomarker for cancer stem cells, although its biological role is unclear. Prominin 2 (PROM2) has also been associated with certain cancers. However, the prognostic value of PROM1 and PROM2 in cancer is controversial. Here, we performed a systematic data analysis to examine whether prominins can function as prognostic markers in human cancers. The expression of prominins was assessed and their prognostic value in human cancers was determined using univariate and multivariate survival analyses, via various online platforms. We selected a group of prominent functional protein partners of prominins by protein-protein interaction analysis. Subsequently, we investigated the relationship between mutations and copy number alterations in prominin genes and various types of cancers. Furthermore, we identified genes that correlated with PROM1 and PROM2 in certain cancers, based on their levels of expression. Gene ontology and pathway analyses were performed to assess the effect of these correlated genes on various cancers. We observed that PROM1 was frequently overexpressed in esophageal, liver, and ovarian cancers and its expression was negatively associated with prognosis, whereas PROM2 overexpression was associated with poor overall survival in lung and ovarian cancers. Based on the varying characteristics of prominins, we conclude that PROM1 and PROM2 expression differentially modulates the clinical outcomes of cancers. 

摘要翻译： 

Prominin 1（PROM1）被认为是癌症干细胞的生物标志物，但其生物学作用尚不明确。Prominin 2（PROM2）也与某些癌症存在关联。然而，PROM1和PROM2在癌症中的预后价值仍存在争议。本研究通过系统性数据分析，探讨prominins能否作为人类癌症的预后标志物。我们利用多种在线平台评估了prominins的表达水平，并通过单变量和多变量生存分析确定了它们在人类癌症中的预后价值。通过蛋白质-蛋白质相互作用分析，我们筛选出一组与prominins相互作用的重点功能蛋白伴侣。随后，我们研究了prominins基因突变和拷贝数变异与多种癌症类型的关系。此外，基于表达水平的相关性分析，我们确定了在特定癌症中与PROM1和PROM2相关的基因。通过基因本体论和通路分析，评估了这些相关基因对多种癌症的影响。我们发现PROM1在食管癌、肝癌和卵巢癌中频繁过表达，且其表达与不良预后呈负相关；而PROM2的过表达与肺癌和卵巢癌的总生存期较差相关。基于prominins的差异化特征，我们得出结论：PROM1和PROM2的表达以不同方式调节癌症的临床结局。

原文链接：

PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis