文章：

乳腺癌中的长链非编码RNA：通往未来方法的纽带

LncRNAs in breast cancer: a link to future approaches

原文发布日期：2022-07-04 

英文摘要：

Breast cancer affects millions of women each year. Despite recent advances in targeted treatments breast cancer remains a significant threat to women’s health. In recent years the development of high-throughput sequencing technologies has advanced the field of transcriptomics shedding light on the role of non-coding RNAs (ncRNAs), including long ncRNAs (lncRNAs), in human cellular function and disease. LncRNAs are classified as transcripts longer than 200nt with no coding potential. These transcripts constitute a diverse group of regulatory molecules essential to the modulation of crucial cellular processes, which dysregulation of leads to disease. LncRNAs exert their regulatory functions through their sequences and by forming complex secondary and tertiary structures that interact with other transcripts, chromatin and/or proteins. Numerous studies have provided evidence of the involvement of LncRNAs in tumor development and disease progression. They possess multiple characteristics that make them novel therapeutic and diagnostic targets. Indeed, the discovery of a novel mechanism by which lncRNAs associated with proteins can induce the formation of phase-separated droplets broadens our understanding of the spatiotemporal control of cellular processes and opens up developing a new treatment. Nevertheless, the role and the molecular mechanisms of many lncRNAs in the regulation of cellular processes and cancer still remain elusive. This is due to the absence of a thorough characterization of the regulatory role of their loci and the functional impact of their aberrations in cancer biology. Here, we present some of the latest advances concerning the role of LncRNAs in breast cancer. 

摘要翻译： 

乳腺癌每年影响数百万女性。尽管靶向治疗领域近期取得进展，乳腺癌仍对女性健康构成重大威胁。近年来，高通量测序技术的发展推动了转录组学领域的进步，揭示了非编码RNA（ncRNAs）——包括长链非编码RNA（lncRNAs）——在人类细胞功能与疾病中的作用。LncRNAs被定义为长度超过200核苷酸且无编码潜力的转录本。这些转录本构成了一类多样化的调控分子，对关键细胞过程的调节至关重要，其失调会导致疾病发生。LncRNAs通过其序列及形成的复杂二级和三级结构与其他转录本、染色质和/或蛋白质相互作用，从而发挥调控功能。大量研究证实LncRNAs参与肿瘤发生与疾病进展。它们具有多重特性，使其成为新型治疗和诊断靶点。事实上，最新发现的lncRNAs与蛋白质相互作用诱导相分离液滴形成的新机制，拓宽了我们对细胞过程时空调控的理解，并为开发新疗法开辟了道路。然而，许多lncRNAs在细胞过程调控和癌症中的作用及分子机制仍不明确，这源于对其基因位点的调控功能及其异常在癌症生物学中的功能影响缺乏系统表征。本文重点介绍LncRNAs在乳腺癌作用机制方面的最新研究进展。

原文链接：

LncRNAs in breast cancer: a link to future approaches