文章：

尤文肉瘤治疗：一种基因治疗方法

Ewing sarcoma treatment: a gene therapy approach

原文发布日期：2023-04-10 

英文摘要：

Ewing sarcoma (ES) is an aggressive malignant tumor, characterized by non-random chromosomal translocations that produce fusion genes. Fusion genes and fusion protein products are promising targets for gene therapy. Therapeutic approaches and strategies vary based on target molecules (nucleotides, proteins) of interest. We present an extensive literature review of active molecules for gene therapy and methods of gene therapy delivery, both of which are necessary for successful treatment. 

摘要翻译： 

尤文氏肉瘤（ES）是一种侵袭性恶性肿瘤，其特征是产生融合基因的非随机染色体易位。融合基因及其蛋白产物是基因治疗中有前景的靶点。根据目标分子（核苷酸、蛋白质）的不同，治疗方法和策略也各不相同。本文对基因治疗的活性分子及递送方法进行了全面文献综述，这两者对成功治疗至关重要。

原文链接：

Ewing sarcoma treatment: a gene therapy approach