文章：

CAFrgDB：一个用于癌症相关成纤维细胞基因及其在癌症中功能的数据库

CAFrgDB: a database for cancer-associated fibroblasts related genes and their functions in cancer

原文发布日期：2023-03-15 

英文摘要：

As one of the most essential components of the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) interact extensively with cancer cells and other stromal cells to remodel TME and participate in the pathogenesis of cancer, which earmarked themselves as new promising targets for cancer therapy. Numerous studies have highlighted the heterogeneity and versatility of CAFs in most cancer types. Thus, the identification and appropriate use of CAF-related genes (CAFGenes) in the context of specific cancer types will provide critical insights into disease mechanisms and CAF-related therapeutic targets. In this study, we collected and curated 5421 CAFGenes identified from small- or large-scale experiments, encompassing 4982 responsors that directly or indirectly participate in cancer malignant behaviors managed by CAFs, 1069 secretions that are secreted by CAFs and 281 regulators that contribute in modulating CAFs in human and mouse, which covered 24 cancer types. For these human CAFGenes, we performed gene expression and prognostic marker-based analyses across 24 cancer types using TCGA data. Furthermore, we provided annotations for CAF-associated proteins by integrating the knowledge of protein-protein interaction(s), drug-target relations and basic annotations, from 9 public databases. CAFrgDB (CAF related Gene DataBase) is free for academic research at http://caf.zbiolab.cn and we anticipate CAFrgDB can be a useful resource for further study of CAFs. 

摘要翻译：

作为肿瘤微环境（TME）中最关键的组成部分之一，癌症相关成纤维细胞（CAFs）与癌细胞及其他基质细胞广泛相互作用，通过重塑TME参与癌症发病机制，这使其成为癌症治疗中极具前景的新靶点。大量研究揭示了CAFs在多数癌症类型中的异质性和多功能性。因此，在特定癌症类型背景下识别并合理运用CAF相关基因（CAFGenes），将为疾病机制和CAF相关治疗靶点研究提供关键见解。本研究收集并整理了从小型及大型实验中鉴定出的5421个CAFGenes，涵盖4982个直接或间接参与CAFs介导的癌症恶性行为的应答因子、1069个由CAFs分泌的分泌因子，以及281个在人或小鼠中参与CAFs调控的调节因子，涉及24种癌症类型。针对人类CAFGenes，我们利用TCGA数据对24种癌症类型进行了基因表达和预后标志物分析。此外，通过整合9个公共数据库中蛋白质相互作用、药物-靶点关系和基础注释信息，我们为CAF相关蛋白提供了系统注释。CAFrgDB（CAF相关基因数据库）可免费用于学术研究，访问地址：http://caf.zbiolab.cn。我们期待CAFrgDB能成为CAFs深入研究的重要资源平台。

原文链接：

CAFrgDB: a database for cancer-associated fibroblasts related genes and their functions in cancer