文章：

从诊断到治疗的新治疗策略的综合综述

a comprehensive review of novel therapeutic strategies from diagnosis to treatment

原文发布日期：2016-12-16 

英文摘要：

Exosomes are nanosized vesicles, released by various cells, which have essential roles in intercellular communication locally and systemically through transporting their contents such as proteins and lipids as well as RNA. It was clear that the element of contents in exosomes reassembled with the emerging of cancers. Over the past decade, researchers paid more attention to the role of exosomes in breast cancer. The purpose of this review was to discuss the details of the biological characteristics of exosomes in breast cancer. The discussion would focus on the role of exosomes in breast cancer development, progression, metastasis and drug resistance, as well as related therapeutic and diagnostic strategies. 

摘要翻译：

外泌体是由多种细胞释放的纳米级囊泡，通过运输蛋白质、脂质及RNA等内容物，在局部和系统性细胞间通讯中发挥关键作用。研究表明，随着癌症的发生发展，外泌体内容物组成会发生显著改变。近十年来，外泌体在乳腺癌中的作用日益受到研究者重视。本综述旨在深入探讨乳腺癌中外泌体的生物学特性，重点阐述其在乳腺癌发生、发展、转移及耐药性中的作用，并相关治疗与诊断策略进行系统性分析。

原文链接：

a comprehensive review of novel therapeutic strategies from diagnosis to treatment