文章：

外泌体在卵巢癌诊断、预后及治疗潜力中的新兴作用：一篇全面综述

Emerging roles of exosomes in diagnosis, prognosis, and therapeutic potential in ovarian cancer: a comprehensive review

原文发布日期：2025-01-22 

英文摘要：

Ovarian cancer is a leading cause of cancer-related deaths in women, and the development of chemoresistance remains a major challenge during and after its treatment. Exosomes, small extracellular vesicles involved in intercellular communication, have emerged as potential biomarkers and therapeutic targets in ovarian cancer. This review summarizes the current literature on differences in exosomal protein/gene expression between chemosensitive and chemoresistant ovarian cancer, and the effects of exosomal modifications on chemotherapeutic response. Clinical studies have identified alterations in several exosomal components from ovarian cancer tissues and serum samples arising as a consequence of chemosensitivity, which indicates their potential usefulness as potential biomarkers for predicting the development of chemoresistance. Interventional investigations from in vitro and in vivo studies demonstrated that modulation of specific exosomal components can influence ovarian cancer cell phenotypes and individual responses to chemotherapy. Exosomal delivery of chemotherapeutic agents, such as cisplatin, has presented as a potential targeted drug delivery strategy for overcoming chemoresistance in preclinical models. In summary, this review highlights the potential for exosomal proteins and genes to be useful biomarkers for predicting chemotherapy response and being therapeutic targets for overcoming chemoresistance in ovarian cancer. However, future research is still needed to validate these findings and explore the clinical utility of exosomal biomarkers and therapeutics in ovarian cancer management. In addition, understanding the molecular mechanisms underlying exosome-mediated chemoresistance may provide valuable insights for the development of personalized therapeutic strategies, improving outcomes for patients with ovarian cancer. 

摘要翻译：

卵巢癌是女性癌症相关死亡的主要原因，而化疗耐药性的形成在其治疗期间和治疗后仍然是一个重大挑战。外泌体作为参与细胞间通讯的小型细胞外囊泡，已成为卵巢癌潜在的生物标志物和治疗靶点。本综述总结了当前关于化疗敏感性和化疗耐药性卵巢癌外泌体蛋白/基因表达差异的文献，以及外泌体修饰对化疗反应的影响。临床研究已发现，卵巢癌组织和血清样本中的几种外泌体成分会因化疗敏感性而发生改变，这表明它们有潜力作为预测化疗耐药性发展的生物标志物。体外和体内研究的干预性实验表明，调节特定外泌体成分可以影响卵巢癌细胞表型及个体对化疗的反应。外泌体递送化疗药物（如顺铂）在临床前模型中已成为克服化疗耐药性的潜在靶向给药策略。总之，本综述强调了外泌体蛋白和基因作为预测化疗反应的有效生物标志物及克服卵巢癌化疗耐药性的治疗靶点的潜力。然而，仍需要未来研究验证这些发现，并探索外泌体生物标志物和治疗在卵巢癌管理中的临床实用性。此外，了解外泌体介导的化疗耐药性的分子机制可能为开发个性化治疗策略提供宝贵见解，从而改善卵巢癌患者的预后。

原文链接：

Emerging roles of exosomes in diagnosis, prognosis, and therapeutic potential in ovarian cancer: a comprehensive review