文章：

两种基因对癌症的影响（或多或少）

Two genetic hits (more or less) to cancer

原文发布日期：2001-11-01

DOI: 10.1038/35101031

类型: Timeline

开放获取: 否

英文摘要：

Most cancers have many chromosomal abnormalities, both in number and in structure, whereas some show only a single aberration. In the era before molecular biology, cancer researchers, studying both human and animal cancers, proposed that a small number of events was needed for carcinogenesis. Evidence from the recent molecular era also indicates that cancers can arise from small numbers of events that affect common cell birth and death processes.

摘要翻译： 

大部分癌症都存在染色体数目和结构的异常，而有些癌症仅出现一个异常。在分子生物学之前，癌症研究者——无论是研究人类还是动物癌症的——认为致癌需要少数事件。近来的分子时代证据也表明，癌症可以由影响细胞出生和死亡过程的小数量事件引起。

原文链接：

Two genetic hits (more or less) to cancer