文章：

缩小成像：小鼠癌症的分子定位

Scaling down imaging: molecular mapping of cancer in mice

原文发布日期：2002-01-01

DOI: 10.1038/nrc701

类型: Review Article

开放获取: 否

要点：

1. Traditional approaches of monitoring cancer growth in mouse models have largely used surface-implanted tumours and caliper measurements.
2. A variety of non-invasive high-resolution imaging methods are now available for the detection and monitoring of deep-seated cancers, as well as their metastases, in transgenic models.
3. Magnetic resonance imaging (MRI) and computed tomography (CT) are primarily used to display internal anatomy of mouse models and are useful tools for phenotyping.
4. The availability of radioisotope, magnetic and/or fluorescent tags is continuously improving our ability to image specific molecular markers in vivo.
5. The use of 'smart' sensors for MRI and optical imaging holds particular promise in sensing and reporting molecular signatures.
6. Technologies are being developed that will ultimately allow cellular protein and signal-pathway profiling. This will further extend our understanding of the molecular pathology of cancer, speed up drug development and can lead to patient-tailored therapies.

要点翻译：

1. 监测小鼠模型中癌症生长的传统方法主要采用表面移植肿瘤和卡尺测量。
2. 目前已有多种无创高分辨率成像技术可用于转基因模型中深部癌症及其转移灶的检测与监测。
3. 磁共振成像（MRI）和计算机断层扫描（CT）主要用于显示小鼠模型的内部解剖结构，是表型分析的重要工具。
4. 放射性同位素、磁性和/或荧光标记技术的不断发展持续提升我们在体内对特定分子标记物进行成像的能力。
5. MRI和光学成像中"智能"传感器的应用为感知和报告分子特征提供了独特前景。
6. 正在开发的技术将最终实现细胞蛋白和信号通路的分析，这将进一步拓展我们对癌症分子病理学的理解，加速药物研发，并有望推动个体化治疗方案的发展。

英文摘要：

The development of miniaturized imaging equipment and reporter probes has improved our ability to study animal models of disease, such as transgenic and knockout mice. These technologies can now be used to continuously monitor in vivo tumour development, the effects of therapeutics on individual populations of cells, or even specific molecules. If these techniques prove effective in mice, they might be translated into the clinic in the future, where they could be used to non-invasively detect and monitor treatment of human cancers.

摘要翻译： 

小型化成像设备和报告探针的发展，提高了我们研究疾病动物模型（如转基因和基因敲除小鼠）的能力。这些技术现已可用于持续监测体内肿瘤的发展、治疗对特定细胞群甚至特定分子的影响。如果这些技术在小鼠中证明有效，未来有望转化为临床应用，用于无创检测和监测人类癌症的治疗。

原文链接：

Scaling down imaging: molecular mapping of cancer in mice