文章：

Prohibitin在癌症中的新兴作用：最新进展

Emerging roles of prohibitins in cancer: an update

原文发布日期：2025-03-08 

英文摘要：

The prohibitin (PHB) family, including PHB1 and its homolog PHB2, is ubiquitously located in different cellular compartments and plays roles in fundamental cellular processes such as proliferation, differentiation, and apoptosis. Accumulating evidence has indicated that this family contributes to the development of numerous diseases in particular cancers. Aberrant expressions of PHBs can been observed in diverse types of human cancer. Depending on their cell compartment-specific attributes and interacting proteins, PHBs are tightly linked to almost all aspects of cancer biology and have distinct bidirectional functions of tumor-suppression or tumor-promotion. However, the roles of PHBs in cancer have yet to be fully characterized and understood. This review provides an updated overview of the pleiotropic effects of PHBs and emphasizes their characteristic roles in each cancer respectively, with the great expectation to identify potential targets for therapeutic approaches and promising molecular biomarkers for cancer diagnosis and prognostic monitor. 

摘要翻译：

抑制素（PHB）家族，包括PHB1及其同源物PHB2，广泛存在于多种细胞区室中，在增殖、分化和凋亡等基本细胞过程中发挥重要作用。越来越多的证据表明该家族参与多种疾病特别是癌症的发生发展。在人类多种癌症类型中均可观察到PHBs的异常表达。根据其细胞区室特异性属性及相互作用蛋白，PHBs与癌症生物学的几乎所有方面都密切相关，并具有抑癌或促癌的双向功能。然而，PHBs在癌症中的作用尚未得到充分表征和理解。本综述提供了PHBs多效作用的最新概述，重点阐述其在各癌种中的特征性角色，以期发现潜在的治疗靶点以及用于癌症诊断和预后监测的有望分子生物标志物。

原文链接：

Emerging roles of prohibitins in cancer: an update