文章：

激活：RhoB在癌症和细胞凋亡中的作用

Actin' up: RhoB in cancer and apoptosis

原文发布日期：2001-11-01

DOI: 10.1038/35101096

类型: Opinion

开放获取: 否

英文摘要：

RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.

摘要翻译： 

RhoB是一种小型GTP酶，负责调节肌动蛋白组织和囊泡运输。在暴露于法尼基转移酶抑制剂、DNA损伤剂或紫杉醇的转化细胞中，RhoB是传递细胞凋亡信号所必需的。小鼠遗传学分析表明，RhoB在正常细胞生理活动中并非必需，但在包括癌症在内的应激相关过程中具有抑制因子或负向调节因子的功能。

原文链接：

Actin' up: RhoB in cancer and apoptosis