文章：

肺微环境：肿瘤生长和转移的重要调节因子

The lung microenvironment: an important regulator of tumour growth and metastasis

原文发布日期：2018-12-10

DOI: 10.1038/s41568-018-0081-9

类型: Review Article

开放获取: 否

英文摘要：

Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Major advances in the identification of key mutational alterations have led to the development of molecularly targeted therapies, whose efficacy has been limited by emergence of resistance mechanisms. US Food and Drug Administration (FDA)-approved therapies targeting angiogenesis and more recently immune checkpoints have reinvigorated enthusiasm in elucidating the prognostic and pathophysiological roles of the tumour microenvironment in lung cancer. In this Review, we highlight recent advances and emerging concepts for how the tumour-reprogrammed lung microenvironment promotes both primary lung tumours and lung metastasis from extrapulmonary neoplasms by contributing to inflammation, angiogenesis, immune modulation and response to therapies. We also discuss the potential of understanding tumour microenvironmental processes to identify biomarkers of clinical utility and to develop novel targeted therapies against lung cancer.

摘要翻译： 

肺癌是全球性的重大健康问题，在世界范围内是癌症相关死亡的主要原因。关键突变改变识别方面的重大进展推动了分子靶向疗法的开发，但其疗效受限于耐药机制的出现。美国食品药品监督管理局批准的血管靶向疗法及近期兴起的免疫检查点疗法，重新激发了人们对肿瘤微环境在肺癌中预后及病理生理作用的研究热情。本综述重点探讨肿瘤重编程的肺微环境如何通过影响炎症、血管生成、免疫调节及治疗反应，促进原发性肺癌和肺外肿瘤肺转移的最新研究进展与新兴概念。我们还将讨论通过理解肿瘤微环境过程来识别临床可用生物标志物，并开发针对肺癌的新型靶向疗法的潜力。

原文链接：

The lung microenvironment: an important regulator of tumour growth and metastasis