文章：

mTOR信号传导和细胞代谢是癌症的相互决定因素

mTOR signalling and cellular metabolism are mutual determinants in cancer

原文发布日期：2018-11-13

DOI: 10.1038/s41568-018-0074-8

类型: Review Article

开放获取: 否

英文摘要：

Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR, which is frequently activated in cancer, controls cell growth and metabolism. mTOR signalling regulates amino acid, glucose, nucleotide, fatty acid and lipid metabolism. Conversely, metabolic inputs, such as amino acids, activate mTOR. In this Review, we discuss how mTOR signalling rewires cancer cell metabolism and delineate how changes in metabolism, in turn, sustain mTOR signalling and tumorigenicity. Several drugs are being developed to perturb cancer cell metabolism. However, their efficacy as stand-alone therapies, similar to mTOR inhibitors, is limited. Here, we discuss how the interdependence of mTOR signalling and metabolism can be exploited for cancer therapy.

摘要翻译： 

致癌信号与代谢改变在癌细胞中相互关联。常被激活的mTOR通路可控制细胞生长与代谢，其信号传导调控氨基酸、葡萄糖、核苷酸、脂肪酸及脂质代谢。反之，氨基酸等代谢输入也会激活mTOR。本文探讨mTOR信号如何重塑癌细胞代谢，并阐释代谢变化如何反向维持mTOR信号与肿瘤发生。目前已有多种靶向癌细胞代谢的药物正在研发，但如同mTOR抑制剂，其单药疗效有限。我们将深入分析如何利用mTOR信号与代谢的互作关系开发癌症疗法。

原文链接：

mTOR signalling and cellular metabolism are mutual determinants in cancer