文章：

干细胞在癌症生长、进展和治疗抵抗中的命运

Stem cell fate in cancer growth, progression and therapy resistance

原文发布日期：2018-09-18

DOI: 10.1038/s41568-018-0056-x

类型: Review Article

开放获取: 否

英文摘要：

Although we have come a long way in our understanding of the signals that drive cancer growth, and how these signals can be targeted, effective control of this disease remains a key scientific and medical challenge. The therapy resistance and relapse that are commonly seen are driven in large part by the inherent heterogeneity within cancers that allows drugs to effectively eliminate some, but not all, malignant cells. Here, we focus on the fundamental drivers of this heterogeneity by examining emerging evidence that shows that these traits are often controlled by the disruption of normal cell fate and aberrant adoption of stem cell signals. We discuss how undifferentiated cells are preferentially primed for transformation and often serve as the cell of origin for cancers. We also consider evidence showing that activation of stem cell programmes in cancers can lead to progression, therapy resistance and metastatic growth and that targeting these attributes may enable better control over a difficult disease.

摘要翻译： 

虽然我们在理解驱动癌症生长的信号以及如何靶向这些信号方面已取得长足进步，但有效控制这种疾病仍是重大的科学和医学挑战。常见的治疗耐药性与疾病复发，很大程度上源于癌症固有的异质性——这种特性使得药物能有效清除部分恶性细胞，却难以全数歼灭。本文通过审视新兴证据，聚焦这种异质性的根本驱动因素，研究表明这些特征往往受正常细胞命运的紊乱及干细胞信号的异常调控所支配。我们探讨未分化细胞如何优先具备转化潜能，并常作为癌症的起源细胞；同时分析相关证据，表明癌症中干细胞程序的激活会导致疾病进展、治疗耐药和转移性生长，而靶向这些特性或将为控制这一棘手疾病开辟新途径。

原文链接：

Stem cell fate in cancer growth, progression and therapy resistance