文章：

解读鳞状细胞癌的细胞起源

Deciphering the cells of origin of squamous cell carcinomas

原文发布日期：2018-05-30

DOI: 10.1038/s41568-018-0024-5

类型: Review Article

开放获取: 否

英文摘要：

Squamous cell carcinomas (SCCs) are among the most prevalent human cancers. SCC comprises a wide range of tumours originated from diverse anatomical locations that share common genetic mutations and expression of squamous differentiation markers. SCCs arise from squamous and non-squamous epithelial tissues. Here, we discuss the different studies in which the cell of origin of SCCs has been uncovered by expressing oncogenes and/or deleting tumour suppressor genes in the different cell lineages that compose these epithelia. We present evidence showing that the squamous differentiation phenotype of the tumour depends on the type of mutated oncogene and the cell of origin, which dictate the competence of the cells to initiate SCC formation, as well as on the aggressiveness and invasive properties of these tumours.

摘要翻译： 

鳞状细胞癌（SCC）是人类最高发的恶性肿瘤之一。这类癌症包含一系列源于不同解剖部位的肿瘤，这些肿瘤具有共同的基因突变特征并表达鳞状分化标志物。鳞状细胞癌既可起源于鳞状上皮组织，也可源自非鳞状上皮组织。本文通过在不同上皮细胞谱系中表达癌基因和/或删除抑癌基因的相关研究，揭示了鳞状细胞癌的起源细胞。现有证据表明，肿瘤的鳞状分化表型取决于突变癌基因的类型和起源细胞——这些因素决定了细胞启动鳞癌形成的能力，同时影响着肿瘤的侵袭性与转移特性。

原文链接：

Deciphering the cells of origin of squamous cell carcinomas