文章：

炎性乳腺癌生物学：肿瘤微环境是关键

Inflammatory breast cancer biology: the tumour microenvironment is key

原文发布日期：2018-04-27

DOI: 10.1038/s41568-018-0010-y

类型: Review Article

开放获取: 否

英文摘要：

Inflammatory breast cancer (IBC) is a rare and aggressive disease that accounts for ~2–4% of all breast cancers. However, despite its low incidence rate, IBC is responsible for 7–10% of breast cancer-related mortality in Western countries. Thus, the discovery of robust biological targets and the development of more effective therapeutics in IBC are crucial. Despite major international efforts to understand IBC biology, genomic studies have not led to the discovery of distinct biological mechanisms in IBC that can be translated into novel therapeutic strategies. In this Review, we discuss these molecular profiling efforts and highlight other important aspects of IBC biology. We present the intrinsic characteristics of IBC, including stemness, metastatic potential and hormone receptor positivity; the extrinsic features of the IBC tumour microenvironment (TME), including various constituent cell types; and lastly, the communication between these intrinsic and extrinsic components. We summarize the latest perspectives on the key biological features of IBC, with particular emphasis on the TME as an important contributor to the aggressive nature of IBC. On the basis of the current understanding of IBC, we hope to develop the next generation of translational studies, which will lead to much-needed survival improvements in patients with this deadly disease.

摘要翻译： 

转移仍是癌症临床治疗中的最大难题。细胞运动是一种基本且古老的细胞行为，它促进转移，并在简单生物中高度保守。在本综述中，我们评估了利用非哺乳动物模型研究细胞运动所获得的对人类癌症具有启示意义的成果。盘基网柄菌、秀丽隐杆线虫、黑腹果蝇和斑马鱼可直接观察细胞在复杂原生环境中迁移，并适合大规模遗传和药理学筛选。我们重点总结了从这些模型中获得的洞见，包括：趋化因子趋化的详细信号网络、基底膜侵袭的新机制、E-钙黏蛋白在集体方向感知中的正向作用、基于果蝇工作筛选并优化用于转移性甲状腺癌的激酶抑制剂，以及斑马鱼在活体成像尤其是血管重塑和肿瘤细胞与宿主组织相互作用研究中的价值。虽然肿瘤细胞和某些宿主细胞的运动促进转移扩散，但肿瘤反应性T细胞的运动可能增强其抗肿瘤效应。因此，阐明所有类型细胞运动的机制至关重要，最终目标是找到联合疗法，既能增强有益细胞的运动，又能阻断有害细胞的扩散。

原文链接：

Inflammatory breast cancer biology: the tumour microenvironment is key