文章：

癌症研究中的类器官

Organoids in cancer research

原文发布日期：2018-04-24

DOI: 10.1038/s41568-018-0007-6

类型: Review Article

开放获取: 否

英文摘要：

The recent advances in in vitro 3D culture technologies, such as organoids, have opened new avenues for the development of novel, more physiological human cancer models. Such preclinical models are essential for more efficient translation of basic cancer research into novel treatment regimens for patients with cancer. Wild-type organoids can be grown from embryonic and adult stem cells and display self-organizing capacities, phenocopying essential aspects of the organs they are derived from. Genetic modification of organoids allows disease modelling in a setting that approaches the physiological environment. Additionally, organoids can be grown with high efficiency from patient-derived healthy and tumour tissues, potentially enabling patient-specific drug testing and the development of individualized treatment regimens. In this Review, we evaluate tumour organoid protocols and how they can be utilized as an alternative model for cancer research.

摘要翻译： 

近期体外三维培养技术（如类器官）的进展为开发新型、更贴近生理状态的人类癌症模型开辟了新途径。此类临床前模型对于更高效地将基础癌症研究成果转化为癌症患者的新型治疗方案至关重要。野生型类器官可从胚胎和成人干细胞中培育而成，并展现出自我组织能力，能模拟来源器官的关键特征。通过对类器官进行基因改造，可在接近生理环境的条件下进行疾病建模。此外，利用患者来源的健康组织和肿瘤组织可高效培育类器官，这为开展患者特异性药物测试及制定个体化治疗方案提供了可能。本综述将评估肿瘤类器官培养方案及其作为癌症研究替代模型的应用潜力。

原文链接：

Organoids in cancer research