文章：

癌症中的非编码RNA网络

Non-coding RNA networks in cancer

原文发布日期：2017-11-24

DOI: 10.1038/nrc.2017.99

类型: Review Article

开放获取: 否

要点：

1. Non-coding RNAs (ncRNAs) participate in complex networks of interactions with other nucleic acids and proteins that often have wide-reaching effects on cell biology.
2. The mechanisms by which ncRNAs work and/or function are routinely dysregulated in various cancers.
3. Dysregulation of ncRNA interactions within cancer molecular pathways contributes to cancer and reveals important new targets for intervention.
4. In cancer, disruptions in ncRNA networks often do not involve just mutations that cause a gross gain-of-function or loss-of-function of a given ncRNA but can also involve mutations that change the sequence and downstream targets of that ncRNA.

要点翻译：

1. 非编码RNA（ncRNAs）与其他核酸和蛋白质形成复杂的相互作用网络，这些作用通常对细胞生物学产生广泛影响。
2. cRNAs的作用机制在多种癌症中常常出现失调。
3. 癌症分子通路中ncRNA相互作用的紊乱不仅促进癌症发展，还为干预治疗揭示了重要的新靶点。
4. 在癌症中，ncRNA网络的破坏通常不仅涉及导致特定ncRNA功能显著增强或丧失的突变，还可能涉及改变该ncRNA序列及其下游靶点的突变。

英文摘要：

Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in which ncRNAs engage can influence numerous molecular targets to drive specific cell biological responses and fates. Consequently, ncRNAs act as key regulators of physiological programmes in developmental and disease contexts. Particularly relevant in cancer, ncRNAs have been identified as oncogenic drivers and tumour suppressors in every major cancer type. Thus, a deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions.

摘要翻译： 

细胞内存在数千种独特的非编码RNA（ncRNA）序列。过去十年的研究改变了我们对ncRNA的看法，从被视为“垃圾”转录产物转变为功能性调控分子，参与染色质重塑、转录、转录后修饰和信号转导等细胞过程。ncRNA所参与的网络可影响众多分子靶点，驱动特定的细胞生物学反应和命运。因此，ncRNA在发育和疾病背景下充当生理程序的关键调控因子。在癌症中尤为重要的是，ncRNA已被证实为每一种主要癌症类型中的致癌驱动因子和肿瘤抑制因子。因此，更深入地理解ncRNA所协调的复杂相互作用网络，将为设计更优治疗干预提供独特机遇。

原文链接：

Non-coding RNA networks in cancer