文章：

脂肪酸合成在癌症中的多重作用

The multifaceted roles of fatty acid synthesis in cancer

原文发布日期：2016-09-23

DOI: 10.1038/nrc.2016.89

类型: Review Article

开放获取: 否

要点：

1. Cancer cells activate de novo fatty acid synthesis to provide essential structural components and substrates for the generation of signalling molecules.
2. Transcriptional regulators of lipid biosynthesis are downstream targets of oncogenes and tumour suppressor pathways.
3. Cancer cells can induce lipid uptake to respond to changes in environmental conditions.
4. Dependence of cancer cells on lipid synthesis or uptake may be defined by the conditions of the tumour microenvironment.
5. Lipid synthesis contributes to cellular processes linked to tumour progression.
6. Multiple lipid metabolism enzymes have been investigated as potential targets for cancer therapy.

要点翻译：

1. 癌细胞激活脂肪酸的从头合成，以提供必要的结构组分及生成信号分子的底物。
2. 脂质生物合成的转录调控因子是癌基因和肿瘤抑制通路的下游靶标。
3. 癌细胞能够诱导脂质摄取以应对环境条件的变化。
4. 癌细胞对脂质合成或摄取的依赖性可能由肿瘤微环境条件决定。
5. 脂质合成参与与肿瘤进展相关的细胞过程。
6. 多种脂质代谢酶已被研究作为癌症治疗的潜在靶点。

英文摘要：

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular process that converts nutrients into metabolic intermediates for membrane biosynthesis, energy storage and the generation of signalling molecules. This Review explores how different aspects of FA synthesis promote tumorigenesis and tumour progression. FA synthesis has received substantial attention as a potential target for cancer therapy, but strategies to target this process have not yet translated into clinical practice. Furthermore, efforts to target this pathway must consider the influence of the tumour microenvironment.

摘要翻译： 

脂质代谢，尤其是脂肪酸（FAs）的合成，是一项将营养物质转化为膜生物合成、能量储存及信号分子生成的代谢中间产物的基本细胞过程。本综述探讨了脂肪酸合成的不同方面如何促进肿瘤发生与进展。脂肪酸合成作为癌症治疗的潜在靶点已受到广泛关注，然而，针对该过程的策略尚未转化为临床实践。此外，靶向这一通路的努力必须考虑肿瘤微环境的影响。

原文链接：

The multifaceted roles of fatty acid synthesis in cancer