文章：

食管腺癌和胃癌：我们应该注意差距吗？

Oesophageal adenocarcinoma and gastric cancer: should we mind the gap?

原文发布日期：2016-04-26

DOI: 10.1038/nrc.2016.24

类型: Review Article

开放获取: 否

要点：

1. There has been a dramatic increase in the incidence of oesophageal adenocarcinoma (OAC) and intestinal-type gastric cancer (GC) arising near the gastric–oesophageal junction (GOJ).
2. OAC and intestinal-type GC share many common molecular features.
3. OAC and intestinal-type GC are derived from the inflammation–metaplasia cascade that occurs in the oesophageal epithelium in OAC and in the gastric epithelium in intestinal-type GC.
4. Barrett oesophagus and OAC may originate from gastric stem cells derived from the cardia.

要点翻译：

1. 食管腺癌和胃食管交界处附近发生的肠型胃癌发病率显著上升。
2. 食管腺癌与肠型胃癌具有许多共同的分子特征。
3. 食管腺癌源于食管上皮的炎症-化生级联反应，而肠型胃癌则源于胃上皮的炎症-化生级联反应。
4. 巴雷特食管和食管腺癌可能起源于贲门的胃干细胞。

英文摘要：

Over recent decades we have witnessed a shift in the anatomical distribution of gastric cancer (GC), which increasingly originates from the proximal stomach near the junction with the oesophagus. In parallel, there has been a dramatic rise in the incidence of oesophageal adenocarcinoma (OAC) in the lower oesophagus, which is associated with antecedent Barrett oesophagus (BO). In this context, there has been uncertainty regarding the characterization of adenocarcinomas spanning the area from the lower oesophagus to the distal stomach. Most relevant to this discussion is the distinction, if any, between OAC and intestinal-type GC of the proximal stomach. It is therefore timely to review our current understanding of OAC and intestinal-type GC, integrating advances from cell-of-origin studies and comprehensive genomic alteration analyses, ultimately enabling better insight into the relationship between these two cancers.

摘要翻译： 

近几十年来，我们观察到胃癌（GC）的解剖分布发生了变化，其越来越多地起源于靠近食管交界处的胃近端。与此同时，与巴雷特食管（BO）相关的食管下段腺癌（OAC）的发病率急剧上升。在此背景下，对于从食管下段至胃远端区域跨越的腺癌的特征描述一直存在不确定性。与此讨论最相关的是OAC与胃近端肠型GC之间的区别（如果有的话）。因此，及时回顾我们目前对OAC和肠型GC的理解，结合细胞起源研究和全面基因组变异分析的进展，最终将有助于更好地洞察这两种癌症之间的关系。

原文链接：

Oesophageal adenocarcinoma and gastric cancer: should we mind the gap?