文章：

RB对生命和死亡的协调调节

Coordinated regulation of life and death by RB

原文发布日期：2003-02-01

DOI: 10.1038/nrc993

类型: Review Article

开放获取: 否

要点：

1. Loss of RB sensitizes cells to apoptosis.
2. Ectopic apoptosis of Rb-null neurons is not a default outcome of inappropriate S-phase entry.
3. RB can be inactivated by phosphorylation and degradation.
4. RB degradation is required for tumour necrosis factor type I receptor-induced apoptosis.
5. Most sporadic human cancers inactivate RB function by exploiting pathways that regulate RB phosphorylation.
6. Loss of RB can only contribute to tumour development under conditions in which apoptosis response is compromised.

要点翻译：

1. RB缺失使细胞对凋亡敏感。
2. Rb缺失神经元的异位凋亡并非不当S期进入的必然结果。
3. RB可通过磷酸化和降解被失活。
4. RB降解是I型肿瘤坏死因子受体诱导凋亡所必需的。
5. 大多数散发性人类癌症通过调控RB磷酸化通路使其功能失活。
6. RB缺失仅在凋亡反应受损的情况下才能促进肿瘤发展。

英文摘要：

Recent studies have shown that RB can inhibit apoptosis, independently of its ability to block cell proliferation. This poses the question of how cells choose to grow or to die when RB becomes inactivated. RB is phosphorylated following mitogenic stimulation, but it is degraded in response to death stimuli. Most sporadic cancers also inactivate RB by phosphorylation, rather than losing RB entirely — possibly to exploit the survival advantage conferred by RB under stress. Drawing from the different mechanisms of RB inactivation, we propose two models for ways in which cells use RB to make the choice of life versus death.

摘要翻译： 

近期研究表明，RB 可在不依赖其阻断细胞增殖能力的情况下抑制凋亡。这引出一个问题：当 RB 失活时，细胞如何决定是生长还是死亡。RB 在有丝分裂原刺激下被磷酸化，但在死亡信号作用下则被降解。大多数散发性癌症也通过磷酸化而非完全丢失 RB 来使其失活——可能是为了在应激条件下利用 RB 带来的生存优势。基于 RB 失活的不同机制，我们提出两种模型，解释细胞如何利用 RB 在生与死之间做出选择。

原文链接：

Coordinated regulation of life and death by RB