文章：

用正电子发射断层扫描技术进行癌症分子成像

Molecular imaging of cancer with positron emission tomography

原文发布日期：2002-09-01

DOI: 10.1038/nrc882

类型: Review Article

开放获取: 否

要点：

1. Positron emission tomography (PET) is a method by which cellular and molecular events can be followed. Injected radiolabelled molecular probes (tracers) are used to map out the underlying biochemistry.
2. Both small-animal and clinical PET are being used to study cancer in living subjects.
3. 2-¹⁸F-fluoro-2-deoxy-D-glucose (FDG) is actively taken up and accumulates in cancer cells. It is useful for diagnosis, staging and monitoring the recurrence of various cancers, including lung, colorectal, melanoma, lymphoma, head and neck, as well as other malignancies.
4. Many tracers already exist for PET that measure cell proliferation, bone remodelling, perfusion, oxygen metabolism, tumour-receptor density and reporter-gene expression. A new generation of tracers is being developed that should help to form libraries of molecular probes for 'customized' imaging approaches.
5. Clinical PET/CT (computed tomography) scanners are now rapidly being installed, and form the basis for merging anatomical information (CT) with functional molecular information (PET) to further advance cancer management with FDG and, eventually, new-generation tracers.
6. Drug and tracer research and development are rapidly evolving and should help to accelerate both the pharmaceutical and imaging industries.

要点翻译：

1. 正电子发射断层成像（PET）是一种能够追踪细胞与分子活动的技术。该方法通过注射放射性标记分子探针（示踪剂）来绘制潜在的生物化学图谱。
2. 目前，小动物PET和临床PET均被用于活体癌症研究。
3. 2-18F-氟代-2-脱氧-D-葡萄糖（FDG）可被癌细胞主动摄取并积累，该特性使其适用于多种癌症（包括肺癌、结直肠癌、黑色素瘤、淋巴瘤、头颈部肿瘤及其他恶性肿瘤）的诊断、分期及复发监测。
4. 现有多种PET示踪剂可用于检测细胞增殖、骨重塑、灌注、氧代谢、肿瘤受体密度及报告基因表达。新一代示踪剂的研发将有助于构建分子探针库，实现"定制化"成像方案。
5. 临床PET/CT（计算机断层扫描）设备目前正快速普及，该技术通过将解剖学信息（CT）与功能分子信息（PET）相融合，不仅推动了FDG在癌症诊疗中的应用，未来还将促进新一代示踪剂的临床应用。
6. 药物与示踪剂的研发正在快速发展，预计将共同推动制药行业和医学影像行业的加速进步。

英文摘要：

The imaging of specific molecular targets that are associated with cancer should allow earlier diagnosis and better management of oncology patients. Positron emission tomography (PET) is a highly sensitive non-invasive technology that is ideally suited for pre-clinical and clinical imaging of cancer biology, in contrast to anatomical approaches. By using radiolabelled tracers, which are injected in non-pharmacological doses, three-dimensional images can be reconstructed by a computer to show the concentration and location(s) of the tracer of interest. PET should become increasingly important in cancer imaging in the next decade.

摘要翻译： 

对与癌症相关的特定分子靶点进行成像，有望实现更早的诊断和更精准的肿瘤患者管理。与解剖学方法相比，正电子发射断层扫描（PET）是一种高灵敏度的无创技术，非常适合癌症生物学的临床前及临床成像。利用注射剂量远低于药理作用剂量的放射性示踪剂，计算机可重建三维图像，显示所关注示踪剂的浓度和分布位置。在未来十年内，PET 将在癌症影像领域发挥日益重要的作用。

原文链接：

Molecular imaging of cancer with positron emission tomography