文章：

整合素在细胞侵袭和迁移中的作用

Role of integrins in cell invasion and migration

原文发布日期：2002-02-01

DOI: 10.1038/nrc727

类型: Review Article

开放获取: 否

要点：

1. As cancer cells become metastatic and as endothelial cells become angiogenic, they develop altered affinity and avidity for their extracellular matrix. Some of these changes are mediated by alterations in the expression of cell-surface molecules known as integrins.
2. Numerous studies have documented dramatic differences in surface expression and distribution of integrins in malignant cells compared with pre-neoplastic tumours of the same type.
3. Integrins are also involved in regulating the activities of proteolytic enzymes that degrade the basement membrane — the initial barrier to surrounding tissue.
4. Integrins are essential for cell migration and invasion, not only because they directly mediate adhesion to the extracellular matrix, but also because they regulate intracellular signalling pathways that control cytoskeletal organization, force generation and survival.
5. Integrins not only send signals to the cell in response to the extracellular environment, but they also respond to intracellular cues and alter the way that they interact with the extracellular environment.
6. Integrin binding to ligands in the extracellular matrix initiates several pro-survival mechanisms to prevent apoptosis.
7. Over the past several years, research has led to the development of integrin and protease inhibitors that are now being tested in clinical trials.

要点翻译：

1. 随着癌细胞变得具有转移性，内皮细胞变得具有血管生成性，它们对细胞外基质的亲和力和结合力发生改变。这些变化部分是由细胞表面分子——整合素表达的改变所介导的。
2. 大量研究记录显示，与同类型肿瘤前病变相比，恶性肿瘤细胞表面整合素的表达和分布存在显著差异。
3. 整合素还参与调节降解基底膜（周围组织的初始屏障）的蛋白水解酶活性。
4. 整合素对细胞迁移和侵袭至关重要，不仅因为它们直接介导与细胞外基质的粘附，还因为它们能调控细胞内信号通路，这些通路控制着细胞骨架组织、力的产生和细胞存活。
5. 整合素不仅响应细胞外环境向细胞内传递信号，还会对细胞内信号作出反应，改变其与细胞外环境的相互作用方式。
6. 整合素与细胞外基质中配体的结合会启动多种促生存机制以防止细胞凋亡。
7. 过去几年中，研究推动了整合素和蛋白酶抑制剂的开发，目前这些抑制剂正处于临床试验阶段。

英文摘要：

As cancer cells undergo metastasis — invasion and migration of a new tissue — they penetrate and attach to the target tissue's basal matrix. This allows the cancer cell to pull itself forward into the tissue. The attachment is mediated by cell-surface receptors known as integrins, which bind to components of the extracellular matrix. Integrins are crucial for cell invasion and migration, not only for physically tethering cells to the matrix, but also for sending and receiving molecular signals that regulate these processes.

摘要翻译： 

在癌细胞发生转移——即侵袭并迁移到新组织的过程中，它们会穿透并附着于靶组织的基底基质。这使癌细胞能够将自己拉入组织内部。这种附着由被称为整合素的细胞表面受体介导，整合素与细胞外基质的成分结合。整合素对细胞的侵袭和迁移至关重要，不仅用于将细胞物理性地锚定在基质上，还用于发送和接收调控这些过程的分子信号。

原文链接：

Role of integrins in cell invasion and migration