文章：

肿瘤血管特化

Specialization of tumour vasculature

原文发布日期：2002-02-01

DOI: 10.1038/nrc724

类型: Review Article

开放获取: 否

要点：

1. Tumours cannot grow without a blood supply. They promote the growth of new vessels through angiogenesis; initiation of angiogenesis (the 'angiogenic switch') is an important and early event in tumour progression.
2. Tumour blood vessels are morphologically different from normal blood vessels; they are tortuous, leaky and surrounded by too few (or abnormal) pericytes.
3. Tumour blood vessels carry distinct molecular markers in the endothelium, pericytes and in the extracellular matrix. Many of these markers are shared by angiogenic vessels in non-malignant conditions.
4. Tumour lymphatics are an important conduit of metastasis. The use of new lymphatic vessel markers has revealed the presence of lymphatic vessels within some, but not all, tumours.
5. Tumour cells themselves might form vessel-like channels within the tumour. These channels are lined by an extracellular matrix, rather than cells; their role as part of the tumour's circulatory system is unclear.
6. The specialization of tumour vessels makes it possible to target diagnostic and therapeutic agents into tumours and provides new targets for drug discovery.

要点翻译：

1. 肿瘤的生长离不开血液供应。它们通过血管生成促进新血管的生长；启动血管生成（即“血管生成开关”）是肿瘤进展过程中一个重要且早期的事件。
2. 肿瘤血管在形态上与正常血管不同：它们迂曲曲折、具有渗漏性，且周围周细胞过少（或异常）。
3. 肿瘤血管在内皮细胞、周细胞和细胞外基质中携带独特的分子标记。其中许多标记物也存在于非恶性条件下的血管生成血管中。
4. 肿瘤淋巴管是转移的重要通道。新型淋巴管标记物的应用揭示了一些（但非所有）肿瘤内部存在淋巴管。
5. 肿瘤细胞本身可能在肿瘤内部形成类似血管的通道。这些通道由细胞外基质而非细胞构成；它们作为肿瘤循环系统组成部分的作用尚不明确。
6. 肿瘤血管的特异性使得针对肿瘤的诊断和治疗剂靶向输送成为可能，并为药物研发提供了新的靶点。

英文摘要：

Tumour blood vessels express markers that are not present in resting blood vessels of normal tissues, but that can be shared by angiogenic vessels in non-malignant conditions. Many of these proteins are functionally important in the angiogenic process. Some tumours also contain lymphatic vessels, as well as channels that consist of cancer cells and their extracellular matrix. These special features of tumour vessels are good targets for cancer therapies.

摘要翻译： 

肿瘤血管表达一些在正常组织静息血管中不存在的标志物，但在非恶性病变中的血管生成过程中也可能出现。许多此类蛋白在血管生成过程中具有重要功能。某些肿瘤还含有淋巴管，以及由癌细胞及其细胞外基质构成的管道。肿瘤血管的这些特征使其成为癌症治疗的良好靶点。

原文链接：

Specialization of tumour vasculature