文章：

MYC：连接选择性转录控制与全球RNA生产

MYC: connecting selective transcriptional control to global RNA production

原文发布日期：2015-09-18

DOI: 10.1038/nrc3984

类型: Review Article

开放获取: 否

要点：

1. MYC is a key integrator of growth-regulatory and oncogenic signalling pathways.
2. MYC binds open chromatin and functions as a transcriptional activator and repressor of selected gene subsets.
3. Detection of MYC binding to chromatin should not be systematically equated to a productive transcriptional event.
4. MYC regulates genes and pathways that can feed back on global RNA production.
5. Various MYC target gene products are crucial for tumour maintenance and may be targeted therapeutically: identifying these key effectors is a main priority in the field.

要点翻译：

1. MYC是生长调控与致癌信号通路的关键整合因子。
2. MYC结合开放染色质，对特定基因子集发挥转录激活和抑制功能。
3. 检测到MYC与染色质结合不应被系统性地等同于有效的转录事件。
4. MYC调控的基因和通路可反向影响全局RNA生成。
5. 多种MYC靶基因产物对肿瘤维持至关重要，或可成为治疗靶点：识别这些关键效应分子是该领域的主要优先任务。

英文摘要：

Two opposing models have been proposed to describe the function of the MYC oncoprotein in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active loci; the other that MYC differentially controls discrete sets of genes, the products of which affect global transcript levels. Here, we argue that differential gene regulation by MYC is the sole unifying model that is consistent with all available data. Among other effects, MYC endows cells with physiological and metabolic changes that have the potential to feed back on global RNA production, processing and turnover. The field is progressing steadily towards a full characterization of the MYC-regulated genes and pathways that mediate these biological effects and — by the same token — endow MYC with its pervasive oncogenic potential.

摘要翻译： 

关于MYC癌蛋白如何塑造细胞转录组，存在两种对立模型：一种认为MYC在所有活跃位点扩增转录；另一种认为MYC差异性调控特定基因集，其产物影响全局转录水平。在此，我们论证差异性基因调控是唯一能解释全部现有数据的统一模型。除其他效应外，MYC赋予细胞生理与代谢变化，这些变化可能反过来影响全局RNA的生成、加工与降解。领域正稳步推进，旨在全面解析介导这些生物学效应的MYC靶基因与通路——同时也揭示MYC普遍致癌潜能的根源。

原文链接：

MYC: connecting selective transcriptional control to global RNA production