文章：

B细胞淋巴瘤的肿瘤微环境

The tumour microenvironment in B cell lymphomas

原文发布日期：2014-07-10

DOI: 10.1038/nrc3774

类型: Review Article

开放获取: 否

要点：

1. B cell lymphomas show a range of extent and composition of tumour microenvironment components, partly reflecting tumour cell content and acquired genetic aberrations harboured by the lymphoma cells.
2. B cell lymphomas home to and co-opt the tumour microenvironment to derive survival and growth signals and to achieve escape from immune surveillance.
3. Tumour–microenvironment interactions are important contributors to both pathogenesis and prognosis of B cell lymphomas.
4. Some aspects of treatment resistance are mediated through tumour–microenvironment interactions, via factors secreted by stromal cells in response to lymphoma cells and cell adhesion-mediated drug resistance.
5. A fundamental understanding of tumour–microenvironment interactions underlies treatment strategies, including immune checkpoint blockade and separating lymphoma cells from their supportive microenvironment.
6. Future studies will include overlaying the genomic aberrations in the lymphoma cells on the composition of the tumour microenvironment and will aim to determine the functional consequences of these interactions.

要点翻译：

1. B细胞淋巴瘤表现出肿瘤微环境成分的不同程度和组成差异，这部分反映了肿瘤细胞含量及淋巴瘤细胞携带的获得性遗传异常。
2. B细胞淋巴瘤能够归巢并利用肿瘤微环境，以获取生存和生长信号，并实现免疫监视逃逸。
3. 肿瘤与微环境的相互作用是B细胞淋巴瘤发病机制和预后的重要影响因素。
4. 治疗耐药性的某些方面是通过肿瘤与微环境的相互作用介导的，包括基质细胞响应淋巴瘤细胞分泌的因子以及细胞粘附介导的耐药性。
5. 对肿瘤与微环境相互作用的基础理解构成了治疗策略的基石，包括免疫检查点阻断以及将淋巴瘤细胞与其支持性微环境分离。
6. 未来研究将重点关注在肿瘤微环境组成上叠加淋巴瘤细胞的基因组异常，并旨在确定这些相互作用的功能性后果。

英文摘要：

B cell lymphomas are cancers that arise from cells that depend on numerous highly orchestrated interactions with immune and stromal cells in the course of normal development. Despite the recent focus on dissecting the genetic aberrations within cancer cells, it has been increasingly recognized that tumour cells retain a range of dependence on interactions with the non-malignant cells and stromal elements that constitute the tumour microenvironment. A fundamental understanding of these interactions gives insight into the pathogenesis of most B cell lymphomas and, moreover, identifies novel therapeutic opportunities for targeting oncogenic pathways, both now and in the future.

摘要翻译： 

B细胞淋巴瘤是一种源于B细胞的癌症，这些细胞在正常发育过程中依赖与多种免疫细胞和基质细胞之间高度协调的相互作用。尽管近年来研究重点在于解析癌细胞内的遗传异常，但人们越来越认识到，肿瘤细胞仍然依赖于与构成肿瘤微环境的非恶性细胞和基质成分之间的多种相互作用。深入理解这些相互作用，不仅有助于阐明大多数B细胞淋巴瘤的发病机制，更为当前及未来靶向致癌通路的新型治疗策略提供了契机。

原文链接：

The tumour microenvironment in B cell lymphomas