文章：

K+通道在癌症中的作用

The roles of K+ channels in cancer

原文发布日期：2013-12-12

DOI: 10.1038/nrc3635

类型: Review Article

开放获取: 否

要点：

1. Ion transport molecules are involved in many physiological and pathological processes.
2. Among ion transporters, potassium channels show the highest variability and the most frequently altered expression in many tumour types.
3. Cell cycle and proliferation, cell migration, invasion and apoptosis are all processes that can be modified by the expression of potassium channels.
4. Permeation-dependent and permeation-independent mechanisms contribute to the roles of potassium channels in oncological processes.
5. The experience gained with pharmacological manipulation of potassium channels in other pathologies might facilitate the use of potassium channels as cancer targets.

要点翻译：

1. 离子转运分子参与许多生理和病理过程。
2. 在离子转运体中，钾离子通道显示出最高的变异性，并在多种肿瘤类型中最常出现表达改变。
3. 细胞周期与增殖、细胞迁移、侵袭和凋亡等过程都可能受到钾离子通道表达的调控。
4. 渗透依赖性和非渗透依赖性机制共同促进了钾离子通道在肿瘤发生发展中的作用。
5. 通过在其他病理条件下对钾离子通道进行药理调控所获得的经验，可能有助于将钾离子通道作为癌症治疗靶点。

英文摘要：

Potassium channels are transmembrane proteins that selectively facilitate the flow of potassium ions down an electrochemical gradient. These molecules have been studied in great detail in the context of cell excitability, but their roles in less cell type-specific functions, such as cell proliferation, angiogenesis or cell migration, have only recently been assessed. Moreover, the importance of these channels for tumour biology has become evident. This, coupled with the fact that they are accessible proteins and that their pharmacology is well characterized, has increased the interest in investigating potassium channels as therapeutic targets in cancer patients.

摘要翻译： 

钾通道是跨膜蛋白，能选择性地促进钾离子沿电化学梯度流动。这些分子在细胞兴奋性背景下已被详尽研究，但其在细胞增殖、血管生成或细胞迁移等细胞类型特异性较低的功能中的作用，直到最近才被评估。此外，这些通道对肿瘤生物学的重要性已变得明显。加之它们是可及的蛋白，且其药理学特征明确，这增加了研究钾通道作为癌症患者治疗靶点的兴趣。

原文链接：

The roles of K+ channels in cancer