文章：

VEGF靶向肿瘤细胞

VEGF targets the tumour cell

原文发布日期：2013-11-22

DOI: 10.1038/nrc3627

类型: Review Article

开放获取: 否

要点：

1. Tumour cells express vascular endothelial growth factor (VEGF) receptors and respond to autocrine and paracrine VEGF signals.
2. VEGF signalling in tumour cells affects tumour functions independently of angiogenesis.
3. VEGF signalling in tumour cells is mediated by VEGF receptor tyrosine kinases (RTKs) and neuropilins (NRPs).
4. NRPs may be at the centre of VEGF signalling because they regulate the function of RTKs and integrins that are crucial for tumour cell function.
5. Autocrine VEGF signalling may be essential for tumour initiation because it regulates the size of the cancer stem cell pool and the self-renewal of cancer stem cells.
6. Therapeutic approaches that aim to target NRPs and VEGF RTKs on tumour cells could be useful to promote tumour regression and to diminish the probability of tumour recurrence, especially when used in combination with VEGF-specific antibodies and other modes of therapy.

要点翻译：

1. 肿瘤细胞表达血管内皮生长因子（VEGF）受体，并对自分泌和旁分泌的VEGF信号产生反应。
2. 肿瘤细胞中的VEGF信号传导以独立于血管生成的方式影响肿瘤功能。
3. 肿瘤细胞中的VEGF信号传导由VEGF受体酪氨酸激酶（RTKs）和神经纤毛蛋白（NRPs）介导。
4. NRPs可能是VEGF信号传导的核心，因为它们调控对肿瘤细胞功能至关重要的RTKs和整合素的功能。
5. 自分泌VEGF信号可能对肿瘤发生至关重要，因为它调控癌症干细胞池的大小和癌症干细胞的自我更新。
6. 旨在靶向肿瘤细胞上NRPs和VEGF RTKs的治疗方法可能有助于促进肿瘤消退并降低肿瘤复发的可能性，特别是与VEGF特异性抗体和其他治疗模式联合使用时。

英文摘要：

The function of vascular endothelial growth factor (VEGF) in cancer is not limited to angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells, and this signalling contributes to key aspects of tumorigenesis, including the function of cancer stem cells and tumour initiation. In addition to VEGF receptor tyrosine kinases, the neuropilins are crucial for mediating the effects of VEGF on tumour cells, primarily because of their ability to regulate the function and the trafficking of growth factor receptors and integrins. This has important implications for our understanding of tumour biology and for the development of more effective therapeutic approaches.

摘要翻译： 

血管内皮生长因子（VEGF）在癌症中的作用不仅限于血管生成和血管通透性。VEGF介导的信号传导发生在肿瘤细胞中，这一信号传导有助于肿瘤发生的关键方面，包括癌症干细胞的功能和肿瘤的起始。除了VEGF受体酪氨酸激酶之外，神经纤毛蛋白对于介导VEGF对肿瘤细胞的影响至关重要，主要是因为它们能够调节生长因子受体和整合素的功能和转运。这对于我们理解肿瘤生物学以及开发更有效的治疗手段具有重要意义。

原文链接：

VEGF targets the tumour cell