文章：

炎症诱导的癌症：肿瘤、免疫细胞和微生物之间的串扰

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

原文发布日期：2013-10-24

DOI: 10.1038/nrc3611

类型: Review Article

开放获取: 否

要点：

1. Inflammation is causally related to cancer development, through processes that involve genotoxicity, aberrant tissue repair, proliferative responses, invasion and metastasis.
2. Major inflammatory pathways that are involved in inflammation-induced carcinogenesis converge at the level of the transcription factors signal transducer and activator of transcription 3 (STAT3) and nuclear factor-κB (NF-κB).
3. Tumours modulate the inflammatory environment by the secretion of soluble growth factors and chemoattractants, which render inflammatory cells suppressive against anticancer T cell responses.
4. In around 20% of all cases, microbial organisms are the causative agents of cancer-inducing inflammation.
5. In addition to bona fide pathogens, pathobionts of the commensal microbiota have recently been recognized as being involved in inflammatory processes that promote tumour growth.
6. A better understanding of the role of the microbiota in inflammation-induced cancer might prospectively lead to targeted antimicrobial therapies against cancer initiation or progression.

要点翻译：

1. 炎症与癌症发生存在因果关系，这一过程涉及遗传毒性、异常组织修复、增殖反应、侵袭和转移。
2. 参与炎症诱导癌变的主要炎症通路最终汇聚于转录因子信号转导与转录激活因子3（STAT3）和核因子κB（NF-κB）层面。
3. 肿瘤通过分泌可溶性生长因子和化学趋化剂调节炎症环境，使炎症细胞对抗癌T细胞反应产生抑制作用。
4. 约20%的癌症病例由微生物病原体引发致癌性炎症。
5. 除典型病原体外，近期研究发现共生微生物群中的致病菌也参与了促进肿瘤生长的炎症过程。
6. 更深入理解微生物群在炎症诱导癌症中的作用，未来可能有望针对癌症起始或进展开发靶向抗菌疗法。

英文摘要：

Inflammation is a fundamental innate immune response to perturbed tissue homeostasis. Chronic inflammatory processes affect all stages of tumour development as well as therapy. In this Review, we outline the principal cellular and molecular pathways that coordinate the tumour-promoting and tumour-antagonizing effects of inflammation and we discuss the crosstalk between cancer development and inflammatory processes. In addition, we discuss the recently suggested role of commensal microorganisms in inflammation-induced cancer and we propose that understanding this microbial influence will be crucial for targeted therapy in modern cancer treatment.

摘要翻译： 

炎症是应对组织稳态失衡的一种基本先天免疫反应。慢性炎症过程影响肿瘤发展的各个阶段以及治疗。在本综述中，我们概述了协调炎症促肿瘤和抗肿瘤作用的主要细胞和分子途径，并讨论了癌症发展与炎症过程之间的相互作用。此外，我们探讨了近期提出的共生微生物在炎症诱发癌症中的作用，并认为理解这种微生物影响对于现代癌症治疗中的靶向治疗至关重要。

原文链接：

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms