文章：

TGFβ在肿瘤微环境中的作用

The roles of TGFβ in the tumour microenvironment

原文发布日期：2013-10-17

DOI: 10.1038/nrc3603

类型: Review Article

开放获取: 否

要点：

1. During the early stages of tumorigenesis, transforming growth factor-β (TGFβ) functions as a tumour suppressor. However, as tumours progress, tumour cells may lose their growth-inhibitory response to TGFβ and may instead respond by initiating epithelial-to-mesenchymal transition and by increasing cell migration.
2. Experimental data support the idea that both loss of and gain of TGFβ signalling is pro-tumorigenic, as mouse models show that the overexpression of TGFβ and the abrogation of signalling results in increased tumour cell metastasis. It is beginning to be appreciated that the effects of TGFβ signalling in the tumour epithelium extend beyond tumour cell-autonomous mechanisms into the tumour microenvironment.
3. Nearly every cell in the tumour microenvironment responds to TGFβ in a unique way, and these diverse biological responses have a variety of effects on tumour progression.
4. Given the pleotropic nature of TGFβ signalling, the numerous downstream signalling events of TGFβ offer new and intriguing targets for therapeutic intervention.
5. Successful therapeutic targeting of TGFβ itself remains a highly desirable goal and the considerable advances in understanding TGFβ signalling, not only in the tumour epithelium but also in the tumour microenvironment, bring the realization of this goal closer.

要点翻译：

1. 在肿瘤发生早期，转化生长因子-β（TGFβ）发挥着肿瘤抑制因子的作用。然而随着肿瘤进展，肿瘤细胞可能丧失对TGFβ的生长抑制反应，转而通过启动上皮-间质转化和增强细胞迁移来作出反应。
2. 实验数据支持"TGFβ信号传导的缺失与增强均具有促肿瘤性"这一观点，小鼠模型表明过度表达TGFβ与信号传导阻断均会导致肿瘤细胞转移增加。学界逐渐认识到TGFβ信号传导在肿瘤上皮中的作用已超越肿瘤细胞自主机制，延伸至肿瘤微环境领域。
3. 肿瘤微环境中几乎所有细胞都以独特方式响应TGFβ，这些多样化的生物学反应对肿瘤进展产生多重影响。
4. 鉴于TGFβ信号传导的多效性，其众多下游信号事件为治疗干预提供了新颖而引人入胜的靶点。
5. 成功靶向TGFβ本身仍是极具价值的目标，随着对TGFβ信号传导（不仅在肿瘤上皮更在肿瘤微环境中）认知的重大进展，这一目标的实现正日趋接近。

英文摘要：

The influence of the microenvironment on tumour progression is becoming clearer. In this Review we address the role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression.

摘要翻译： 

微环境对肿瘤进展的影响正变得日益清晰。在本综述中，我们探讨了一种关键信号通路——转化生长因子-β（TGF-β）——在调控肿瘤微环境组分中的作用，以及其如何促进肿瘤进展。

原文链接：

The roles of TGFβ in the tumour microenvironment