文章：

Krüppel-like癌症的因素

Krüppel-like factors in cancer

原文发布日期：2013-09-24

DOI: 10.1038/nrc3582

类型: Review Article

开放获取: 否

要点：

1. The Krüppel-like factors (KLFs) are a family of transcriptional regulators linked by a triple zinc finger DNA-binding domain.
2. In normal tissues, KLFs control a broad number of key cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency.
3. KLF expression and function are altered in a large number of human cancers, and KLFs regulate cancer cell proliferation and apoptosis, metastasis, tumour microenvironment and cancer stem cells.
4. KLFs have context-dependent functions, partly mediated by molecular switches, such as p53, p21 or SIN3 transcription regulator homologue A (SIN3A), alternative splicing and post-translational modifications.
5. KLFs cross-regulate and compensate for each other in cancer, although these functions remain to be fully defined.
6. Understanding the mechanisms of KLF function in cancer will probably lead to new translational discoveries for cancer diagnosis and treatment.

要点翻译：

1. Krüppel样因子（KLFs）是一个通过三重锌指DNA结合结构域连接的转录调节因子家族。
2. 在正常组织中，KLFs调控众多关键细胞过程，包括增殖、分化、迁移、炎症和多能性。
3. 在多种人类癌症中，KLF的表达和功能发生改变，它们调节癌细胞的增殖与凋亡、转移、肿瘤微环境及癌症干细胞。
4. KLF具有情境依赖性功能，这部分通过分子开关（如p53、p21或SIN3转录调节同源蛋白A）、可变剪接和翻译后修饰介导。
5. KLFs在癌症中存在相互交叉调节和代偿作用，尽管这些功能尚未完全明确。
6. 理解KLF在癌症中的作用机制，很可能为癌症诊断和治疗带来新的转化性发现。

英文摘要：

Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.

摘要翻译： 

Krüppel样因子（KLFs）是一类能与DNA结合的转录调控因子家族，在细胞增殖、分化、迁移、炎症及多能性等多种细胞过程中发挥多样且关键的作用。本综述探讨了目前已知的17种KLF在各类与癌症相关过程中的作用及其调控机制。重要的是，KLF的功能具有情境依赖性：某些KLF在正常细胞与癌细胞中的作用不同，在癌症的发生与进展阶段表现各异，且在不同癌种中也存在差异。我们还提出了该领域亟待解决的关键问题，这些问题有望推动癌症生物学中新的转化研究与重要发现。

原文链接：

Krüppel-like factors in cancer