文章：

利用天基调查为地球上的癌症研究提供信息

Using space-based investigations to inform cancer research on Earth

原文发布日期：2013-04-12

DOI: 10.1038/nrc3507

类型: Review Article

开放获取: 否

要点：

1. In the microgravity environment of space, cells assemble into multicellular three-dimensional constructs.
2. Reduced gravitational force has been shown to have far-ranging effects on cell growth and function, including effects on gene expression, the production of soluble factors, cell signalling and cytoskeletal organization.
3. Suspension-based cell culture can be achieved using the rotating wall bioreactor, clinostat, random positioning machine and magnetic levitation. These models provide certain conditions that are observed during culture in microgravity, including lack of sedimentation, reduced fluid shear, optimized cellular colocation and three-dimensional growth.
4. Research approaches derived from space-based investigations may be applicable to advance our knowledge of tumour biology, as well as inform the development of new anticancer technologies and therapeutic strategies.

要点翻译：

1. 在太空的微重力环境中，细胞会组装成多细胞三维结构。
2. 研究表明，重力减弱对细胞生长和功能具有广泛影响，包括改变基因表达、可溶性因子生成、细胞信号传导及细胞骨架组织。
3. 基于悬浮的细胞培养可通过旋转壁生物反应器、回转器、随机定位仪和磁悬浮技术实现。这些模型能模拟微重力培养中的特定条件，包括无沉降现象、流体剪切力减弱、细胞共定位优化及三维生长。源
4. 自太空研究的方法或可应用于拓展我们对肿瘤生物学的认知，并为开发新型抗癌技术与治疗策略提供思路。

英文摘要：

Experiments conducted in the microgravity environment of space are not typically at the forefront of the mind of a cancer biologist. However, space provides physical conditions that are not achievable on Earth, as well as conditions that can be exploited to study mechanisms and pathways that control cell growth and function. Over the past four decades, studies have shown how exposure to microgravity alters biological processes that may be relevant to cancer. In this Review, we explore the influence of microgravity on cell biology, focusing on tumour cells grown in space together with work carried out using models in ground-based investigations.

摘要翻译： 

在微重力环境下进行的实验通常不会出现在癌症生物学家的脑海中。然而，太空提供了地球上无法实现的物理条件，以及可被用来研究控制细胞生长和功能的机制和通路的条件。在过去四十年中，研究表明，暴露于微重力会改变可能与癌症相关的生物过程。在本综述中，我们探讨了微重力对细胞生物学的影响，重点研究了在太空中生长的肿瘤细胞以及使用地面模型进行的研究工作。

原文链接：

Using space-based investigations to inform cancer research on Earth