文章：

河马通路和人类癌症

The Hippo pathway and human cancer

原文发布日期：2013-03-07

DOI: 10.1038/nrc3458

类型: Review Article

开放获取: 否

要点：

1. The Hippo pathway is an evolutionarily conserved regulator of tissue growth.
2. The Hippo pathway controls multiple cellular functions that are central to tumorigenesis, including proliferation and apoptosis.
3. Hippo pathway mutations in mice and flies give rise to tumours.
4. Hippo pathway activity seems to be frequently deregulated in different human cancers but most Hippo pathway genes are not commonly mutated.
5. Molecular events such as sensitivity to the mechanical properties of tumours and crosstalk with other cancer pathways might cause Hippo pathway deregulation in human cancers.
6. Hippo pathway therapeutics and new avenues to modulate pathway activity are beginning to emerge.

要点翻译：

1. Hippo通路是一种进化上保守的组织生长调控机制。  
2. 该通路控制着与肿瘤发生密切相关的多种细胞功能，包括增殖和凋亡。
3. 在小鼠和果蝇中，Hippo通路突变会引发肿瘤。
4. 在多种人类癌症中，Hippo通路活性常常出现异常，但大多数Hippo通路基因并未普遍发生突变。
5. 对肿瘤机械特性的敏感性以及与其他癌症通路的交互作用等分子事件，可能导致人类癌症中Hippo通路的失调。
6. 目前针对Hippo通路的治疗方法以及调控该通路活性的新策略正在逐步涌现。

英文摘要：

The Hippo pathway controls organ size in diverse species, whereas pathway deregulation can induce tumours in model organisms and occurs in a broad range of human carcinomas, including lung, colorectal, ovarian and liver cancer. Despite this, somatic or germline mutations in Hippo pathway genes are uncommon, with only the upstream pathway gene neurofibromin 2 (NF2) recognized as a bona fide tumour suppressor gene. In this Review, we appraise the evidence for the Hippo pathway as a cancer signalling network, and discuss cancer-relevant biological functions, potential mechanisms by which Hippo pathway activity is altered in cancer and emerging therapeutic strategies.

摘要翻译： 

Hippo信号通路调控多种物种的器官大小，其失调可在模式生物中诱发肿瘤，并广泛存在于人类多种癌种中，包括肺、结直肠、卵巢和肝癌。尽管如此，Hippo通路基因的体细胞或生殖系突变却较为罕见，目前仅上游基因神经纤维瘤病2型（NF2）被公认为真正的抑癌基因。本文综述了Hippo通路作为癌症信号网络的证据，探讨其在癌症中的相关生物学功能、活性改变的潜在机制及新兴治疗策略。

原文链接：

The Hippo pathway and human cancer