文章：

核膜环境及其与癌症的关系

The nuclear envelope environment and its cancer connections

原文发布日期：2012-02-16

DOI: 10.1038/nrc3219

类型: Review Article

开放获取: 否

要点：

1. Nuclear morphology is often altered in cancer. Irregularity in nuclear contours is a feature used by pathologists in diagnostic cytology.
2. The nuclear envelope provides a specialized microenvironment within the nucleus. It is also the site where a series of protein–protein interactions take place to connect the cytoskeleton to the interior of the nucleus.
3. Constituents of the nuclear envelope — lamins, nuclear pore complexes and lipid membranes — have key roles in several processes that affect tumour cell biology and response to therapy.
4. Changes in the abundance or the function of components of the nuclear envelope in tumour cells can cause the occurrence of dysmorphic nuclei and can deregulate cell migration, intracellular signalling, DNA repair, cell division and gene expression.
5. Tracking the abundance of molecular components of the nuclear envelope environment and enhanced methods to visualize changes at the nuclear envelope could potentially be used for the prognostic assessment of cancer patients.

要点翻译：

1. 核形态在癌症中常发生改变。核轮廓的不规则性是病理学家在诊断细胞学中使用的特征。
2. 核膜在核内提供了一个特殊的微环境。它也是一系列蛋白质-相互作用的场所，将细胞骨架与核内部连接起来。
3. 核膜的组成成分——核纤层蛋白、核孔复合物和脂质膜——在影响肿瘤细胞生物学及治疗反应的多个过程中起着关键作用。
4. 肿瘤细胞中核膜组分丰度或功能的改变可导致畸形核的出现，并可能使细胞迁移、细胞内信号传导、DNA修复、细胞分裂和基因表达失调。
5. 追踪核膜环境分子组分的丰度及改进核膜变化可视化方法，可能用于癌症患者的预后评估。

英文摘要：

Because of the association between aberrant nuclear structure and tumour grade, nuclear morphology is an indispensible criterion in the current pathological assessment of cancer. Components of the nuclear envelope environment have central roles in many aspects of cell function that affect tumour development and progression. As the roles of the nuclear envelope components, including nuclear pore complexes and nuclear lamina, are being deciphered in molecular detail there are opportunities to harness this knowledge for cancer therapeutics and biomarker development. In this Review, we summarize the progress that has been made in our understanding of the nuclear envelope and the implications of changes in this environment for cancer biology.

摘要翻译： 

由于异常核结构与肿瘤分级之间的关联，核形态学是当前癌症病理评估中不可或缺的标准。核膜环境的组分在影响肿瘤发展和进展的细胞功能许多方面中发挥核心作用。随着包括核孔复合体和核纤层在内的核膜组分的作用在分子层面被逐步解析，利用这些知识开发癌症治疗手段和生物标志物的机遇也随之出现。在本综述中，我们总结了我们在理解核膜方面取得的进展，以及这一环境变化对癌症生物学的影响。

原文链接：

The nuclear envelope environment and its cancer connections