文章：

细胞谱系和细胞死亡：秀丽隐杆线虫和癌症研究

Cell lineage and cell death: Caenorhabditis elegans and cancer research

原文发布日期：2010-12-02

DOI: 10.1038/nrc2984

类型: Review Article

开放获取: 否

要点：

1. The invariant nature of the development of cell lineages in the nematode worm Caenorhabditis elegans has made it a useful model for understanding the mechanisms of cell lineage control and cell death.
2. Many of the genes that regulate cell death and lineage development have homologues in mammals.
3. Mapping cell lineage development in the nematode has been particularly informative for understanding the regulation of haematopoiesis in mammals, with many of the genes that regulate cell lineage being deregulated in leukaemia and lymphoma.
4. Further understanding of the regulation of cell fate in C. elegans and mammals should identify new targets for anticancer drug development.

要点翻译：

1. 线虫细胞谱系发育过程的恒定性特征，使其成为研究细胞谱系调控与细胞死亡机制的理想模型。
2. 调控细胞死亡与谱系发育的众多基因在哺乳动物中均存在同源基因。
3. 通过绘制线虫细胞谱系发育图谱，我们尤其深化了对哺乳动物造血调控机制的认识——许多调控细胞谱系的基因在白血病和淋巴瘤中均出现异常表达。
4. 对线虫与哺乳动物细胞命运调控机制的进一步研究，必将为抗癌药物研发识别新的靶点。

英文摘要：

Cancer is a complex disease in which cells have circumvented normal restraints on tissue growth and have acquired complex abnormalities in their genomes, posing a considerable challenge to identifying the pathways and mechanisms that drive fundamental aspects of the malignant phenotype. Genetic analyses of the normal development of the nematode Caenorhabditis elegans have revealed evolutionarily conserved mechanisms through which individual cells establish their fates, and how they make and execute the decision to survive or undergo programmed cell death. The pathways identified through these studies have mammalian counterparts that are co-opted by malignant cells. Effective cancer drugs now target some of these pathways, and more are likely to be discovered.

摘要翻译： 

癌症是一种复杂的疾病，其细胞逃避了对组织生长的正常控制，并在其基因组中获得了复杂的异常，这给识别驱动恶性表型基本方面的通路和机制带来了相当大的挑战。对秀丽隐杆线虫正常发育的遗传分析揭示了进化上保守的机制，通过这些机制，单个细胞建立其命运，并做出和执行生存或经历程序性细胞死亡的决定。通过这些研究确定的通路在哺乳动物中有对应的同源通路，这些通路被恶性细胞所利用。有效的癌症药物现在针对其中一些通路，并且可能会发现更多的通路。

原文链接：

Cell lineage and cell death: Caenorhabditis elegans and cancer research