文章：

肾素-血管紧张素系统和癌症：老狗，新把戏

The renin–angiotensin system and cancer: old dog, new tricks

原文发布日期：2010-10-22

DOI: 10.1038/nrc2945

类型: Review Article

开放获取: 否

要点：

1. This Review presents a contemporary update of the renin–angiotensin system (RAS), explaining its links to cancer through tissue remodelling, inflammation, angiogenesis and apoptosis.
2. In vitro, animal and clinical studies indicate that the RAS is frequently dysregulated in malignancy and correlates with poor patient outcomes.
3. Antagonism of the RAS mostly suppresses tumour growth, metastasis and angiogenesis in a broad range of experimental models of malignancy.
4. Retrospective studies in humans provide some evidence that long-term use of angiotensin-converting enzyme inhibitors might modulate cancer growth and progression.
5. The potential for retooling current drugs that target the RAS for application to cancer therapy is discussed.

要点翻译：

1. 本综述对肾素-血管紧张素系统（RAS）提出了当代更新，阐释了其通过组织重塑、炎症、血管生成和细胞凋亡与癌症产生的关联。
2. 体外实验、动物研究及临床观察表明，RAS在恶性肿瘤中经常失调，并与患者不良预后相关。
3. 在多种恶性肿瘤实验模型中，RAS拮抗作用大多能抑制肿瘤生长、转移和血管生成。
4. 人类回顾性研究提供了一些证据，表明长期使用血管紧张素转换酶抑制剂可能调节癌症的生长和进展。
5. 文中还探讨了将现有靶向RAS药物重新应用于癌症治疗的潜力。

英文摘要：

For cancers to develop, sustain and spread, the appropriation of key homeostatic physiological systems that influence cell growth, migration and death, as well as inflammation and the expansion of vascular networks are required. There is accumulating molecular and in vivo evidence to indicate that the expression and actions of the renin–angiotensin system (RAS) influence malignancy and also predict that RAS inhibitors, which are currently used to treat hypertension and cardiovascular disease, might augment cancer therapies. To appreciate this potential hegemony of the RAS in cancer, an expanded comprehension of the cellular actions of this system is needed, as well as a greater focus on translational and in vivo research.

摘要翻译： 

癌症的发生、持续和扩散，需要占用影响细胞生长、迁移和死亡，以及炎症和血管网络扩张的关键稳态生理系统。越来越多的分子和体内证据表明，肾素-血管紧张素系统（RAS）的表达和作用会影响恶性肿瘤，并预测目前用于治疗高血压和心血管疾病的RAS抑制剂可能会增强癌症治疗效果。为了认识RAS在癌症中的这种潜在主导作用，需要对该系统的细胞作用有更深入的理解，并更加重视转化和体内研究。

原文链接：

The renin–angiotensin system and cancer: old dog, new tricks