文章：

多梳蛋白群：在癌症中误入歧途的谱系通路的导航员

Polycomb group proteins: navigators of lineage pathways led astray in cancer

原文发布日期：2009-11-01

DOI: 10.1038/nrc2736

类型: Review Article

开放获取: 否

要点：

1. The Polycomb group (PcG) proteins regulate cell fate decisions during development and differentiation. They form multiprotein repressive complexes called Polycomb repressive complexes (PRCs), which modify chromatin.
2. The PcG proteins bind and repress the promoters of hundreds of genes encoding proteins with roles in cell fate determination.
3. It is unclear how PcG proteins are displaced and recruited to different subsets of target genes during cell fate decisions. However, cell fate transcription factors (CFTFs) and long non-coding RNAs (ncRNAs) are emerging as potential regulators.
4. There is growing evidence that many PcG target genes are silenced in advanced cancer and that this may be the result of an epigenetic switch to DNA methylation during neoplastic progression.
5. Several PcG proteins are known to be deregulated in cancer. We propose that the deregulation of CFTFs and long ncRNAs also leads to the misexpression of PcG target genes.

要点翻译：

1. 多梳家族（PcG）蛋白在发育和分化过程中调控细胞命运决定。它们形成被称为多梳抑制复合物（PRCs）的多蛋白抑制复合体，通过修饰染色质发挥作用。
2. PcG蛋白能结合并抑制数百个编码细胞命运决定相关蛋白质的基因启动子。
3. 目前尚不清楚在细胞命运决定过程中，PcG蛋白如何被置换并招募至不同靶基因亚群。然而，细胞命运转录因子（CFTFs）和长链非编码RNA（ncRNAs）正逐渐成为潜在调控因子。
4. 越来越多证据表明，许多PcG靶基因在晚期癌症中处于沉默状态，这可能是肿瘤进展过程中表观遗传转换为DNA甲基化的结果。
5. 已知数种PcG蛋白在癌症中出现失调。我们认为CFTFs和长链ncRNAs的失调同样会导致PcG靶基因的错误表达。

英文摘要：

The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.

摘要翻译： 

Polycomb（PcG）蛋白是一类转录抑制因子，在发育和分化过程中调控谱系选择。近期研究加深了我们对PcG蛋白如何调控细胞命运决定，以及其失调如何潜在促进癌症的理解。在本综述中，我们讨论了长链非编码RNA（ncRNA）和被我们称为细胞命运转录因子的一类转录因子，在调控PcG与靶基因结合中的新兴作用。我们也推测了它们的失调如何促进肿瘤发生。

原文链接：

Polycomb group proteins: navigators of lineage pathways led astray in cancer