文章：

P53与新陈代谢

p53 and metabolism

原文发布日期：2009-09-17

DOI: 10.1038/nrc2715

类型: Review Article

开放获取: 否

要点：

1. Metabolic alterations are common features of cancer cells and have recently been shown to have an important role in the maintenance of malignancies.
2. p53 is a key tumour suppressor protein that has a diverse range of functions — including the ability to promote apoptosis, senescence and DNA repair — each of which helps to prevent cancer development. A role for p53 in regulating metabolic pathways has also recently been identified, suggesting that this is another mechanism by which p53 helps to stall malignant progression.
3. Several functions of p53 promote oxidative phosphorylation and dampen glycolysis in cells; disruption of this balance is associated with mutations in p53 and oncogenic transformation.
4. p53 also has a key role in regulating cell growth and autophagy, thereby helping to coordinate the cell's response to nutrient starvation.
5. Altered metabolism can contribute to malignant transformation, and cancer cells become dependent on these changes. Understanding the role of p53 in the regulation of metabolism may provide some interesting potential targets for the development of new cancer therapies.

要点翻译：

1. 代谢改变是癌细胞的常见特征，并且近期研究表明其在维持恶性肿瘤恶性表型中具有重要作用。
2. p53是一种关键的肿瘤抑制蛋白，具有广泛的功能——包括促进细胞凋亡、衰老和DNA修复的能力——这些功能均有助于预防癌症发生。近期研究还发现p53在调控代谢通路中发挥作用，提示这可能是p53抑制恶性肿瘤进展的另一机制。
3. p53的多种功能可促进细胞氧化磷酸化并抑制糖酵解；这种平衡的破坏与p53突变和致癌转化相关。
4. p53在调控细胞生长和自噬过程中同样起关键作用，从而有助于协调细胞应对营养缺乏的状态。
5. 代谢改变可促进恶性转化，癌细胞会变得依赖这些变化。理解p53在代谢调控中的作用可能为开发新型癌症疗法提供潜在靶点。

英文摘要：

Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression.

摘要翻译： 

尽管癌症中的代谢改变已被观察了近一个世纪，但直到最近才揭示了这些变化背后的机制，并认识到代谢转化的重要性。研究表明，p53能够响应代谢变化，并通过多种机制影响代谢通路。这些活性对肿瘤抑制的作用复杂且可能相当出人意料：有些反映了无需明显激活的基础p53水平的功能，而另一些甚至可能促进而非抑制肿瘤进展。

原文链接：

p53 and metabolism