文章：

转移：从播散到器官特异性定植

Metastasis: from dissemination to organ-specific colonization

原文发布日期：2009-04-01

DOI: 10.1038/nrc2622

类型: Review Article

开放获取: 否

要点：

1. Metastasis progression can be viewed as a stepwise sequence of events, which is mediated by different classes of metastasis genes.
2. For each type of cancer, the clinical course of these events occurs with distinct temporal kinetics and in unique organ sites.
3. The long latency period of certain tumour types suggests the further evolution or 'speciation' of malignant cells in the microenvironments of a particular organ. The acquisition of pro-metastatic functions earlier during primary tumour formation might enable other cancer subtypes to relapse more quickly.
4. The organ specificity of metastatic cells is determined by unique infiltrative and colonization functions required after their dissemination from a primary tumour.
5. New insights into the importance of latency and organ-specific colonization should be considered in the design of optimized therapeutic strategies.

要点翻译：

1. 转移进程可被视为由不同类别转移基因介导的系列级联事件。
2. 每种癌症类型中，这些事件的临床进程具有独特的时序动力学特征，并发生于特定器官部位。
3. 某些肿瘤类型的长期潜伏期提示恶性细胞在特定器官微环境中持续演化或形成“物种特异性”。若原发肿瘤早期即获得促转移功能，可能导致其他癌症亚型更快复发。
4. 转移细胞的器官特异性取决于其从原发灶播散后所需的独特浸润与定植功能。
5. 在设计优化治疗策略时，应充分考虑关于潜伏期重要性及器官特异性定植机制的新见解。

英文摘要：

Metastasis to distant organs is an ominous feature of most malignant tumours but the natural history of this process varies in different cancers. The cellular origin, intrinsic properties of the tumour, tissue affinities and circulation patterns determine not only the sites of tumour spread, but also the temporal course and severity of metastasis to vital organs. Striking disparities in the natural progression of different cancers raise important questions about the evolution of metastatic traits, the genetic determinants of these properties and the mechanisms that lead to the selection of metastatic cells.

摘要翻译： 

远处器官的转移是大多数恶性肿瘤的凶兆特征，但不同癌症的这一过程自然史各异。细胞的起源、肿瘤的内在特性、组织亲和性以及循环模式不仅决定了肿瘤扩散的部位，也决定了向重要器官转移的时间进程和严重程度。不同癌症在自然进展上的显著差异，引发了关于转移特征演化、这些特性的遗传决定因素，以及导致转移细胞选择的机制等重要问题。

原文链接：

Metastasis: from dissemination to organ-specific colonization