文章：

上皮和间充质状态之间的转变：恶性和干细胞特征的获得

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

原文发布日期：2009-03-05

DOI: 10.1038/nrc2620

类型: Review Article

开放获取: 否

要点：

1. Transitions between epithelial and mesenchymal states underlie epithelial cell plasticity and contribute to tumour progression and intratumoural heterogeneity.
2. The epithelial–mesenchymal transition (EMT) is triggered by a diverse set of stimuli including growth factor signalling, tumour–stromal cell interactions and hypoxia. There is a significant crosstalk among EMT-inducing signals and transcription factors that can lead to stable reprogramming of epithelial cells to mesenchymal states.
3. EMT has been shown to result in cancer cells with stem cell-like characteristics that have a propensity to invade surrounding tissue and display resistance to certain therapeutic interventions.
4. The mesenchymal–epithelial transition (MET) may have a role in the reversion of disseminated mesenchymal tumour cells to a more epithelial state in distant metastases.
5. microRNAs have been identified as a new class of EMT regulators, in part owing to their regulation of EMT-inducing transcription factors.

要点翻译：

1. 上皮细胞与间充质状态之间的转换是上皮细胞可塑性的基础，并促进肿瘤进展和肿瘤内异质性。
2. 上皮-间充质转化（EMT）由多种刺激触发，包括生长因子信号传导、肿瘤-基质细胞相互作用和缺氧。EMT诱导信号与转录因子之间存在显著的交叉对话，可导致上皮细胞向间充质状态的稳定重编程。
3. 研究显示，EMT可产生具有干细胞样特征的癌细胞，这类细胞易侵袭周围组织并对某些治疗干预产生耐药性。
4. 间充质-上皮转化（MET）可能在播散性间充质肿瘤细胞逆转至更接近上皮状态的远处转移中发挥作用。
5. microRNA已被确定为新型EMT调控因子，部分原因在于其对EMT诱导转录因子的调控作用。

英文摘要：

Transitions between epithelial and mesenchymal states have crucial roles in embryonic development. Emerging data suggest a role for these processes in regulating cellular plasticity in normal adult tissues and in tumours, where they can generate multiple, distinct cellular subpopulations contributing to intratumoural heterogeneity. Some of these subpopulations may exhibit more differentiated features, whereas others have characteristics of stem cells. Owing to the importance of these tumour-associated phenotypes in metastasis and cancer-related mortality, targeting the products of such cellular plasticity is an attractive but challenging approach that is likely to lead to improved clinical management of cancer patients.

摘要翻译： 

上皮与间充质状态之间的转换在胚胎发育中起着关键作用。新兴数据表明，这些过程在调节正常成体组织和肿瘤中的细胞可塑性方面具有一定作用，在肿瘤中，它们可以产生多个不同的细胞亚群，从而促进肿瘤内异质性。其中一些亚群可能表现出更为分化的特征，而另一些则具有干细胞特征。由于这些肿瘤相关表型在转移和癌症相关死亡中的重要性，针对这种细胞可塑性的产物进行靶向治疗是一种有吸引力但具有挑战性的方法，有望改善癌症患者的临床管理。

原文链接：

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits