文章：

肿瘤中胰岛素和胰岛素样生长因子的信号传导

Insulin and insulin-like growth factor signalling in neoplasia

原文发布日期：2008-12-01

DOI: 10.1038/nrc2536

类型: Review Article

开放获取: 否

要点：

1. Insulin and insulin-like growth factor (IGF) signalling systems are ancient and involve regulation of physiology in ways beyond their well-known medically recognized roles concerning regulation of carbohydrate metabolism and growth.
2. There is substantial experimental and clinical evidence that cancer cells express insulin and IGF1 receptors, and that these receptors are important activators of the Akt and mitogen-activated protein kinase signalling networks in neoplastic tissue.
3. Population studies provide substantial direct and circumstantial evidence that cancer risk and cancer prognosis are influenced by IGF1 and insulin levels.
4. Preclinical evaluation of drug candidates that target IGF1 and/or insulin signalling has revealed antineoplastic activity.
5. At least 10 different drug candidates are being evaluated in clinical trials; early results have justified expansion of clinical trial programmes.
6. Energy metabolism is an important topic in cancer research. IGF1 and insulin might have roles, along with other regulators, in mediating effects of perturbations of whole organism energy balance (for example, dietary excess, caloric restriction and exercise) on cellular energy physiology.

要点翻译：

1. 胰岛素和胰岛素样生长因子（IGF）信号系统是古老的系统，其生理调节功能远超众所周知的医学公认作用——调节碳水化合物代谢和生长。
2. 大量实验和临床证据表明，癌细胞表达胰岛素和IGF1受体，且这些受体是肿瘤组织中Akt和丝裂原活化蛋白激酶信号网络的重要激活因子。
3. 群体研究提供了大量直接和间接证据，表明IGF1和胰岛素水平会影响癌症风险和癌症预后。
4. 针对IGF1和/或胰岛素信号通路的候选药物的临床前评估已显示出抗肿瘤活性。
5. 目前至少有10种不同的候选药物正在临床试验中进行评估；早期结果证明了扩大临床试验计划的合理性。
6. 能量代谢是癌症研究中的重要课题。IGF1和胰岛素可能与其他调节因子一起，在介导全身能量平衡扰动（如饮食过量、热量限制和运动）对细胞能量生理的影响中发挥作用。

英文摘要：

Insulin and insulin-like growth factors (IGFs) are well known as key regulators of energy metabolism and growth. There is now considerable evidence that these hormones and the signal transduction networks they regulate have important roles in neoplasia. Epidermiological, clinical and laboratory research methods are being used to investigate novel cancer prevention and treatment strategies related to insulin and IGF signalling. Pharmacological strategies under study include the use of novel receptor-specific antibodies, receptor kinase inhibitors and AMP-activated protein kinase activators such as metformin. There is evidence that insulin and IGF signalling may also be relevant to dietary and lifestyle factors that influence cancer risk and cancer prognosis. Recent results are encouraging and have justified the expansion of many translational research programmes.

摘要翻译： 

胰岛素和胰岛素样生长因子（IGF）被认为是能量代谢和生长的关键调节因子。现有大量证据表明，这些激素及其调控的信号转导网络在肿瘤发生中具有重要作用。流行病学、临床和实验室研究方法正被用于探索与胰岛素及IGF信号相关的新型癌症预防和治疗策略。正在研究的药物策略包括使用新型受体特异性抗体、受体激酶抑制剂以及AMP激活蛋白激酶激活剂（如二甲双胍）。有证据显示，胰岛素和IGF信号也可能与影响癌症风险和预后的饮食及生活方式因素相关。近期研究结果令人鼓舞，已推动多项转化研究项目的扩展。

原文链接：

Insulin and insulin-like growth factor signalling in neoplasia